Admin Control Panel

New Post | Settings | Change Layout | Edit HTML | Edit posts | Sign Out

MEBO Private Facebook Group
to join : go to
or contact
Ubiome Gut EXPLORER : 10% OFF
Join/Watch the weekly
TMAU UP Podcasts

Videos : TMAU stories

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact map@meboresearch.org
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
BannerFans.com
RESEARCH DETAILS

DONATIONS THRU 31-NOV-2016:
£ 943.03/GBP
$ 568.00/USD

TOTAL at today's ROE
£0.80/GBP = $1.00/USD

£1,398.07 = $1,745.14

MEBO UK PAYPAL FOR TRINZYME

********
MEBO US PAYPAL FOR TRINZYME

Your currency will be automatically converted to USD or GBP by PayPal.

Option: pay with your credit card instead of PayPal account by clicking on either Donate button above.

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed

Subscribe to Blog

Enter your email address:

Delivered by FeedBurner

You will be sent a verification email

Subscribe in a reader

Blog Archive

Friday, April 8, 2011

Table of FMO3 variants provided by Dr John Cashman

Table of FMO3 variants provided by Dr John Cashman 

Dr John Cashman kindly provided some of his research papers for us to view at the Washington meetup. We have chosen to look at the table of FMO3 variants in one of these papers.

As seen in Prof Elizabeth Shephard's slideshow, the FMO3 protein consists of 532 amino acids. Whilst building these amino acids, in theory it means there could be 532 points where mutations could occur that would affect the construction of the final FMO3 protein.

In this table, Dr Cashman has listed some of the common amino acid numbers where mutations occur. Some are severe mutations, other have less or no effect, although some can reduce activity if in combination with another (such as 158 - 258)

Notice that one change to amino acid 158 is about 40% common in ethnic groups.

2.5% have a combo of 158 - 308 which is said to be present in 2.5% of the population. However, this is only regarded as likely to cause a mild deficiency in FMO3 function if both the mutations are on the same chromosome (i.e. from the same parent) .

The paper also lists some drugs that commonly use FMO3 function and the affect a deficiency may have on them.

0 comments:

Post a Comment