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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Saturday, April 14, 2018

Professor Yoshika Sekine's Slideshow PATM study

Click on icon & scroll down to see
complete slideshow presentation

Click English translation
The MEBO Research community around the world is most grateful to researcher Professor Yoshika Sekine, for carrying out a much needed study into PATM and for publishing a paper on his findings (in Japanese). In addition, we are most grateful to Professor Sekine and his colleague, Dr. Yasuhiro Konishi, M.D., of the Konishi Clinic in Japan for presenting a classic case of PATM in the Japanese TV show "World Astonishing News", as noted in a post in this blog, "Japanese Study: Elevated petrochemicals in PATM". This research discusses the petrochemicals found in skin gas analysis of sufferers of this syndrome. You have provided our international community with information we can now use in our Raising Awareness Campaign, and for this, we are profoundly grateful!

‘An exploratory study on “people allergic to me” syndrome based on measurement of trace gases released from skin surface and microbial species in nasal cavity of a patient’


There exist some people who claim his/her body odor provokes allergy-like reactions of people in their near vicinity, which include sneezing, runny nose, cough, itchy eyes, and red eyes. Such a diathesis, called “people allergic to me (PATM)”, has been gradually recognized in other countries. However, the term “PATM” has been hardly heard in Japan, and there have been no reports focusing on PATM in academic journals so far. After receiving a request for advice from a male subject, we conducted a medical interview, measurement of trace gases released from human skin surface, measurement of volatile chemicals from the subject’s underwear, and microbiological test of the nasal cavity of the patient. The results showed that greater amounts of chemicals, such as toluene and xylene, were detected in skin-gas samples from the subject than in those from a control subject. Moreover, some chemicals, such as hexane, propionaldehyde, and toluene, which showed relatively high levels of emission from the subject’s skin, were also detected in the underwear of the subject. The microbial species that was isolated from the nasal cavity of the subject with the highest abundance was Staphylococcus epidermidis (Bacilli; Bacillales), which is known as a resident skin flora. In addition, Arthrobacter phenanthrenivorans (Actinobacteria; Micrococcales), which releases a ditch-like smell, was cultured on isolation medium, and its presence might have a relationship with the PATM condition. Furthermore, Rhodotorula mucilaginosa (Basidiomycota; Sporidiales), which is a fungus that is known to cause red water scale in bathrooms/washrooms, was isolated from the nasal cavity of the subject. To the best of our knowledge, the isolation of this latter species from the human nasal cavity has not previously been reported. Taken together, there is a possibility that PATM is not a product of patients’ imagination but represents a genuine disease that has yet-to-be-investigated.

KAWAKAMI, Yuji & SEKINE, Yoshika & KIMURA, Keita & TODAKA, Michihito & ODA, Hisayuki. (2018). An exploratory study on "people allergic to me" syndrome based on measurement of trace gases released from skin surface and microbial species in nasal cavity of a patient. Indoor Environment. 21. 19-30. 10.7879/siej.21.19.

Online link to the full publication:


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