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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country

MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Blog Archive

Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Sunday, May 4, 2008

Choline Requirements and Role in Brain Development

Choline: Dietary Requirements and Role in Brain Development
Lisa M. Sanders PhD, R.D., and Steven H. Zeisel MD, PhD

Choline is needed for the maintenance of the structural integrity and signaling functions of cell membranes, for neurotransmission, and for transport of lipids and as a source of methyl groups...choline deficiency can cause disorders in many bodily systems, including liver, muscle, and lymphocytes in humans and, additionally, the kidney, pancreas, and developing brain and nervous system in animals.

full article:

Only a small amount of dietary choline is metabolized to form acetylcholine, a neurotransmitter frequently used by the nerves controlling breathing, heart rate, and skeletal muscles. Acetylcholine is also important in the portions of the brain responsible for memory and mood.

Zeisel SH. Choline and brain development. In: Bowman BR, Russell RM, eds. Present Knowledge in Nutrition Vol 1 . 9th ed. Washington, DC: ILSI Press; 2006:352-360.

Steven Zeisel, MD., Ph.D. Professor and Chair, Department of Nutrition Professor, Department of Pediatrics, University of North Carolina

Dr. Zeisel's research focuses on nutrient metabolism, with special emphasis on establishing human nutrient requirements and on identifying cancer-causing agents which are produced within our bodies. His work has focused on the nutrient choline as it relates to: a) transmembrane signal transduction (diacylglycerol and protein kinase) and carcinogenesis in liver, b) perinatal brain development, c) human nutrient requirements, and d) choline and secretion of components of milk by isolated mammary epithelial cells.

for more information on Dr. Zeisel's research:


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