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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country

MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Sunday, May 4, 2008

Choline Requirements and Role in Brain Development

Choline: Dietary Requirements and Role in Brain Development
Lisa M. Sanders PhD, R.D., and Steven H. Zeisel MD, PhD

Choline is needed for the maintenance of the structural integrity and signaling functions of cell membranes, for neurotransmission, and for transport of lipids and as a source of methyl groups...choline deficiency can cause disorders in many bodily systems, including liver, muscle, and lymphocytes in humans and, additionally, the kidney, pancreas, and developing brain and nervous system in animals.

full article:

Only a small amount of dietary choline is metabolized to form acetylcholine, a neurotransmitter frequently used by the nerves controlling breathing, heart rate, and skeletal muscles. Acetylcholine is also important in the portions of the brain responsible for memory and mood.

Zeisel SH. Choline and brain development. In: Bowman BR, Russell RM, eds. Present Knowledge in Nutrition Vol 1 . 9th ed. Washington, DC: ILSI Press; 2006:352-360.

Steven Zeisel, MD., Ph.D. Professor and Chair, Department of Nutrition Professor, Department of Pediatrics, University of North Carolina

Dr. Zeisel's research focuses on nutrient metabolism, with special emphasis on establishing human nutrient requirements and on identifying cancer-causing agents which are produced within our bodies. His work has focused on the nutrient choline as it relates to: a) transmembrane signal transduction (diacylglycerol and protein kinase) and carcinogenesis in liver, b) perinatal brain development, c) human nutrient requirements, and d) choline and secretion of components of milk by isolated mammary epithelial cells.

for more information on Dr. Zeisel's research:


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