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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
click to read more
more details : karen.james@meboresearch.org

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Wednesday, June 25, 2008

1999 paper : 'Fish odor' case due to dimethylglycine

from 1999 :

This paper tells of a man(38) who smelt of a fish odor since 5, and was negative for TMAU. He was finally diagnosed as having too much dimethylglycine in his blood. A DNA test seemed to confirm a mutant homozygous gene for the Dimethylglycine dehydrogenase enzyme. He also complained of muscle fatigue.

In this case, choline is to be avoided because it is metabolized in the body to dimethyglycine. Its not to do with gut bacteria. Betaine is also to be avoided, as can be seen in the graph. Possibly most of our betaine is derived from choline breakdown.

For this enzyme, B2 is the co-factor, and folate could also be implicated.

A main point is that his FMO3 enzyme seemed to be fine, and he even done well for (low) TMA levels after eating fish. This may be a test worth doing if you feel it could be an issue.

Pubmed abstract : http://www.ncbi.nlm.nih.gov/pubmed/10102904
full paper : http://www.clinchem.org/cgi/content/full/45/4/459

This subject may be returned to in the next few days, for elaboration and in case of errors

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