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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Tuesday, June 17, 2008

Drug metabolizing enzymes : FMO3 is one such enzyme

These sort of educational posts will be ongoing, and as I learn along the way, I'll pass it along to you.

Drug-metabolizing enzymes

This seems to be a broad 'trade' term for a group of metabolizing enzymes that deals with many chemicals , the FMO family (flavin monooxygenase) being one of the group. There are currently 5 generally accepted FMOs. We will be discussing the enzymes that deal with the metabolism of drugs as well as with many other chemicals, including internally produced hormones, and of external sources, such as the gut and environment airborne chemicals through the skin.

As the process of metabolic detoxification is explained in Wikipedia, "An animal's metabolism can produce harmful substances which it can then make less toxic through oxidation, conjugation and excretion of molecules from cells or tissues. This is called xenobiotic metabolism."

There seem to be 2 main groupings of such enzymes :
1: the 'nonsynthetic reaction' group (oxidation, reduction, hydrolysis, cyclization, and decyclization reactions). The FMO family are part of this group.
2: the 'synthetic reaction' group (the conjugative group, which add something to a 'chemical')

The main purpose of this type of enzyme seems to be to keep the main circulating blood as clear of toxins as possible by altering them into easily excretable non-toxic compounds, and to properly activate chemicals supposed to do some good.

Good explanantion :

short quick link:
pdf format. Not sure how relevant :

As a loose analogy, which may not be totally correct but gives a sense of the concept, regarding drug-metabolizing enzymes:

If you think of theses enzymes as supermarket checkout cashiers, and the 'substrates' are the (fat soluble) shoppers to be processed (turned into water soluble). There are express checkouts and disability checkouts, all designed to make processing the shoppers as efficient as possible. Say the 'express' cashier is the FMO3 enzyme, and not very good. Then a big queue builds up there, but most of the FMO3-substrate shoppers can go join other queues instead, to queue behind people with trolleys. Sadly, unlike most 'substrates', TMA doesnt have another option apart from FMO3.


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