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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Tuesday, June 17, 2008

Drug metabolizing enzymes : FMO3 is one such enzyme

These sort of educational posts will be ongoing, and as I learn along the way, I'll pass it along to you.

Drug-metabolizing enzymes

This seems to be a broad 'trade' term for a group of metabolizing enzymes that deals with many chemicals , the FMO family (flavin monooxygenase) being one of the group. There are currently 5 generally accepted FMOs. We will be discussing the enzymes that deal with the metabolism of drugs as well as with many other chemicals, including internally produced hormones, and of external sources, such as the gut and environment airborne chemicals through the skin.

As the process of metabolic detoxification is explained in Wikipedia, "An animal's metabolism can produce harmful substances which it can then make less toxic through oxidation, conjugation and excretion of molecules from cells or tissues. This is called xenobiotic metabolism."

There seem to be 2 main groupings of such enzymes :
1: the 'nonsynthetic reaction' group (oxidation, reduction, hydrolysis, cyclization, and decyclization reactions). The FMO family are part of this group.
2: the 'synthetic reaction' group (the conjugative group, which add something to a 'chemical')

The main purpose of this type of enzyme seems to be to keep the main circulating blood as clear of toxins as possible by altering them into easily excretable non-toxic compounds, and to properly activate chemicals supposed to do some good.

Good explanantion :

short quick link:
pdf format. Not sure how relevant :

As a loose analogy, which may not be totally correct but gives a sense of the concept, regarding drug-metabolizing enzymes:

If you think of theses enzymes as supermarket checkout cashiers, and the 'substrates' are the (fat soluble) shoppers to be processed (turned into water soluble). There are express checkouts and disability checkouts, all designed to make processing the shoppers as efficient as possible. Say the 'express' cashier is the FMO3 enzyme, and not very good. Then a big queue builds up there, but most of the FMO3-substrate shoppers can go join other queues instead, to queue behind people with trolleys. Sadly, unlike most 'substrates', TMA doesnt have another option apart from FMO3.


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