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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, August 4, 2008

Vitamin & mineral deficiencies : An unknown quantity in bloodborne odors

Note : none of the following should be regarded as advice. It is posted only as something to think about. It should not be regarded as wholly accurate and is posted in the spirit of promoting discussion on it.

If someone has what is known on the forums as Fecal Body Odor, which can involve many differing smells, we can safely assume that something is 'not normal'. Obviously, it is important to make sure the metabolizing enzymes are functioning correctly, as well as looking for any reason for the metabolic enzymes being constantly overloaded, but another factor that may be being overlooked is vitamin and mineral deficiencies.

Very often, these metabolic enzymes depend on a vitamin or mineral to function. As most of us know, the FMO3 enzyme requires riboflavin (B2). In theory, it would seem possible that a B2 deficiency could cause that enzyme to work deficiently (but there is no evidence to support this in practice). Another B vitamin involved less directly in FMO3 function is niacin (in its role of being the vitamin required for NADPH). It is unclear if this could be an issue in FMO3 function, since the experts do not seem to advise its use (perhaps NADPH is involved in so many reactions that a deficiency is unlikely. Niacin is also unpleasant in large doses). The status of the B Vitamins is probably a good starting point, since they are often co-factors in the drug metabolizing enzymes (the xenobiotic enzymes, of which the FMO family of enzymes are a part of). B Vitamins are also often produced by good gut bacteria. Biotin in particular.

The main point is, if someone smells of strange smells, longterm as a group it would make sense to be aware of the typical sufferer vitamin/mineral status to see if there is any deficiency trend. Hopefully someday this can be done in a research environment. At the moment it must be assumed it is not an issue (due to no test results or research available)

Reference links:
Vitamins and their coenzyme function : http://www.med.unibs.it/~marchesi/vitamins.html
Example of B2 being recommended for TMAU, although they are suggesting extra to try and stimulate any residual FMO3 enzyme to maximum effect.
http://rarediseases.info.nih.gov/GARD/QnA.aspx?

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