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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Tuesday, August 5, 2008

What makes skunk musk smelly ? Anecdotal report from 1990

This is posted only out of interest as to what the compounds were that made skunk musk smelly. Sadly a few of us may possibly smell skunk-like at times. At the moment there is no medical explanation as to why. This research was done in 1990, although often these type of results will be contradicted in other tests.

Sulphur atoms are often responsible for endowing chemical compounds with nasty smells. Think of the bad-eggs smell of hydrogen sulphide. Raw onions owe their powerful aroma to the molecule propenyl thiosulphinate...
This next quote is of interest because it demonstrates how smelly compounds can be tested. Perhaps someday such a test could be the standard 'diagnosis' test for people with bloodborne body odor or halitosis
...He separated the secretions using a gas chromatograph in which the vapour of the musk was passed through a capillary tube, 12 metres long, coated with silicone oil and heated to 250 Degree C. The separated components were identified by mass spectrometry, which measures their relative molecular mass, as they emerged from the gas chromatograph...
The final quotes are posted purely of general interest.
...In the Journal of Chemical Ecology (vol 16, p 2057) Wood reveals that skunk musk consists of seven major components, each at a concentration of more than 1 per cent. Three of them are thiols, and three are thioacetates. (These are compounds related to thiols but have a thioacetate group, CH3CSS, attached to a sulphur atom instead of a hydrogen atom.) The last one is an alkaloid.

The thiols are trans-2-butene-1-thiol, which is the major component and has the most repulsive smell, 3-methyl-1-butanethiol, which smells only marginally less objectionable, and 2-quinoline methane-thiol...
...The new compounds discovered by Wood are the thioacetates of the above thiols. One of them, trans-2-butenyl thioacetate, was completely unknown before. Previous investigators had wrongly identified it as a disulphide, which is a compound with a chemical bond between two sulphur atoms. Wood believes that thioacetates are the compounds that give a skunk the ability to remind its victim of the encounter for several days. They react slowly with water to release more of the strong-smelling thiols...
...Wood suggests that the best way to remove skunk odour is to wash with a highly alkaline laundry soap. The thiols are slightly acidic and neutralising the hydrogen atom of the S-H group will turn them into ions. This will not only make them more soluble in water, but will also deodorise them because these ions are not volatile.


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