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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Tuesday, August 5, 2008

What makes skunk musk smelly ? Anecdotal report from 1990

This is posted only out of interest as to what the compounds were that made skunk musk smelly. Sadly a few of us may possibly smell skunk-like at times. At the moment there is no medical explanation as to why. This research was done in 1990, although often these type of results will be contradicted in other tests.

http://www.newscientist.com/article/mg12717282.900-science-the-seven-deadly-smells-of-a-skunk-.html

Sulphur atoms are often responsible for endowing chemical compounds with nasty smells. Think of the bad-eggs smell of hydrogen sulphide. Raw onions owe their powerful aroma to the molecule propenyl thiosulphinate...
This next quote is of interest because it demonstrates how smelly compounds can be tested. Perhaps someday such a test could be the standard 'diagnosis' test for people with bloodborne body odor or halitosis
...He separated the secretions using a gas chromatograph in which the vapour of the musk was passed through a capillary tube, 12 metres long, coated with silicone oil and heated to 250 Degree C. The separated components were identified by mass spectrometry, which measures their relative molecular mass, as they emerged from the gas chromatograph...
The final quotes are posted purely of general interest.
...In the Journal of Chemical Ecology (vol 16, p 2057) Wood reveals that skunk musk consists of seven major components, each at a concentration of more than 1 per cent. Three of them are thiols, and three are thioacetates. (These are compounds related to thiols but have a thioacetate group, CH3CSS, attached to a sulphur atom instead of a hydrogen atom.) The last one is an alkaloid.

The thiols are trans-2-butene-1-thiol, which is the major component and has the most repulsive smell, 3-methyl-1-butanethiol, which smells only marginally less objectionable, and 2-quinoline methane-thiol...
...The new compounds discovered by Wood are the thioacetates of the above thiols. One of them, trans-2-butenyl thioacetate, was completely unknown before. Previous investigators had wrongly identified it as a disulphide, which is a compound with a chemical bond between two sulphur atoms. Wood believes that thioacetates are the compounds that give a skunk the ability to remind its victim of the encounter for several days. They react slowly with water to release more of the strong-smelling thiols...
...Wood suggests that the best way to remove skunk odour is to wash with a highly alkaline laundry soap. The thiols are slightly acidic and neutralising the hydrogen atom of the S-H group will turn them into ions. This will not only make them more soluble in water, but will also deodorise them because these ions are not volatile.

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