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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

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UK residents survey : Prof Shephard/MEBO (until 31/1/21) click to visit survey
click to Read more/less

Prof Elizabeth Shephard is conducting a TMAU fact-finding survey for UK RESIDENTS. She plans to use it to raise awareness with decision-makers, such as perhaps MPs. It closes 31 Jan 21.

who is the survey intended for ?
UK residents who identify with TMAU

Living with TMAU study

We invite you to participate in a research project entitled ‘Living with TMAU’.

click to visit survey

survey full url :
https://meboresearch.co.uk/index.php/living-with-tmau-lwtmau-study/

Participation in the project will involve completion of a short questionnaire, which aims to capture the experiences of those living with the condition. There are two questionnaires.

For individuals with TMAU over the age of 18

For a parent or guardian of a child with TMAU.

The results from the questionnaires will be compiled to produce a report that will be available for you to use, for example, to lobby your MP. The findings will be used to reach out to policy makers in the UK to have TMAU recognised as an invisible disability and to make people aware of what it is like to live with the disorder. The report will be made available on the MEBO, UK website.

To complete either questionnaire you must be over 18 and resident in the UK. The questionnaire responses are anonymous and no personal identifiers will be collected.

The questionnaire closes 11:59 pm (GMT) Sunday 31st January 2021.

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Friday, October 24, 2008

Milk thistle: big booster of detox function (35% ?) in a normal liver

This is written only to promote awareness of options and may not be accurate. At this point in us understanding systemic odor problems, it should be expected that a bad reaction is more likely.

It would seem safe to assume that someone with bloodborne body odor/halitosis is likely overworking/saturating one or more of their xenobiotic metabolizing enzymes (or other cell enzymes),to the point the system is letting the toxins circulate in the bloodstream untreated (trimethylamine being an example).

Many of these cell enzymes can be induced in some way, but this can be a double-edged reaction. For example, St Johns wort has been shown to induce CYP3A4 (the busiest of the CYP enzymes). How beneficial this could be is unknown. It could be a bad thing.

Many foods (mainly fruit, vegetables, herbs and spices ) will have some type of effect on detox enzymes (grapefruit juice is known to greatly inhibit the CYP3A4 enzyme present in the small intestine), but herbs and spices likely often have a very powerful effect on detox enzymes in particular (either way). This is known as 'modulating' the enzyme (either inducing it or inhibiting it).

One particular herb known to have benefits to a liver with potential of working better, is milk thistle (silymarin being the active ingredient thought to cause the benefit). Dr Michael Murray ND explains the benefit in this article.

One of the key manners in which silymarin enhances detoxification reaction is preventing the depletion of glutathione. As discussed above, the level of glutathione in the liver is critically linked to the liver's ability to detoxify. The higher the glutathione content, the greater the liver's capacity to detoxify harmful chemicals. Typically, when we are exposed to chemicals which can damage the liver including alcohol, the concentration of glutathione in the liver is substantially reduced. This reduction in glutathione makes the liver cell susceptible to damage. Silymarin not only prevents the depletion of glutathione induced by alcohol and other toxic chemicals, but has been shown to increase the level of glutathione of the liver by up to 35%.5 Since the ability of the liver to detoxify is largely related to the level of glutathione in the liver, the results of this study seem to indicate that silymarin can increase detoxification reactions by up to 35%.
http://www.doctormurray.com/articles/Silybin.htm

Sadly, again, at this point, if you have a compromised general detox enzyme (or other enzyme), it's unknown what type of reaction you will have, and also whether it's a bad reaction. For instance it could be an enzyme substrate and therefore causing overload, or it could be inhibiting an enzyme (as indoles inhibit FMO3). At the moment nothing can be assumed when dealing with unaccepted bloodborne body odor/halitosis conditions. Also, it's unknown if you would be accidentally feeding an unwanted microbe in the gut.

When people react badly to drugs (Adverse Drug Reactions ; one of the biggest causes of death) (note: the linked site is selling a product but the info on ADRs is probably a fair reflection, as opposed to how the official medical system would summarize ADRs. Also, at this point the Genova Detoxigenomic test seems more extensive and cheaper.) , it is likely not an allergic reaction, but more often a sign of a weakness in an enzyme pathway that either deals with the drug or is modulated by it (or both). Probably one or more of the xenobiotic metabolizing enzymes. The same is probably true of herbs since they do seem to be powerful enzyme modulators, presumably always mostly beneficial in a 'normal enzyme' person. Someday drug prescriptions will be based on pharmacogenetics (personalized medicine), but for now they treat everyone as if they are 'normal' and really just guess.

Note: Cynarin, the active ingredient in artichoke, is said to have a similar, more gentler effect than silymarin (the active ingredient in milk thistle). It may be an alternative experimental choice. (Dr Michael Murray ND link on cynarin)

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