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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Saturday, November 22, 2008

List of the pH of common cleansers for (suggested) Trimethylaminuria management

The following list the pH of some of the more popular cleansers/soaps.

Context: One of the suggestions on The trimethylaminuria paper published on the NIH Gene reviews site, by Drs. Phillips and Shephard, London, for a TMAU (trimethylaminuria) management protocol is the use of an acid soap/cleanser to attempt to neutralize some of the highly alkaline trimethylamine. For this reason this list is published, until a more comprehensive one can be found. Thanks to Sonya from the MSN Body Odor forum for posting the link.

Use of acid soaps and body lotions. Trimethylamine is a strong base (pKa 9.8). Thus, at pH 6.0, less than 0.02% of trimethylamine exists as the volatile free base. The use of soaps and body lotions with a pH close to that of normal skin (pH 5.5-6.5) helps retain secreted trimethylamine in a less volatile salt form that can be removed by washing.
AHAVA Soaps 5.5
Alpha Hydrox Foaming Face Wash 6.1-6.5
Alpha Hydrox Optimum Series Moisturizing Cleanser 6.3-6.5
Beauty Without Cruelty Vitamin C Cleanser 6.0-6.5And now J&J vows to remove formaldehyde from its products by the end of 2015.And now J&J vows to remove formaldehyde from its products by the end of 2015.
Cellex-C Betaplex Cleanser 5.0-5.5
Cetaphil cleanser 6.7
Dermalogica Exfoliants: 3.4-3.9
Dermalogica The Bar 5.5
Dermalogica Dermal Clay Cleanser 6.2
Dial Soap (liquid and bar) 9.5
Dove Bar, Baby Dove Bar 7
Dr. Bonner Liquid Soaps 8
Earth Science Clarifying Facial Wash 5.0-5.5
Earth Science ADE Creamy Cleanser 5
Earth Science Apricot Facial Scrub Cream 5
Earth Science Aloe-Gel Cleanser Liquid 5
Ecco Bella Normal/Oily Cleanser 6.5-7.0
GlyTone Mild Cream Wash 3.4%GA, 3.5
GlyTone Mild Gel Wash 4.7% GA, 3.8
GlyTone Wipe Away Cleanser 7.8% GA, 3.8
Irish Spring Soap 9.5
Ivory Soap 9.5
Jevelle Magick Clear Gentle Apricot Scrub 5
Johnson & Johnson Head to Toe Baby Wash 6.5-7.0
Johnson & Johnson 5.5 5.5
Lever 2000 9
MD Forte Cleansers pH 3.8
MD Forte Facial Cleanser II 15%GA 3.8
MD Formulations Sensitive Skin Cleanser 4.4
MD Formulations Basic Facial Cleanser 5.5
MD Formulations Oily/Problem Cleanser 3.8
Neutrogena Deep Clean Facial Cleanser 3.8-4.6
Neutrogena Deep Clean Cream Cleanser 2.8-3.8
Neutrogena Deep Clean Cleansing Cloths N/A
Neutrogena Extra Gentle Cleanser 5.6-6.2
Neutrogena Extra Gentle Cleansing Bar 6.0-7.5
Neutrogena Facial Cleansing Bar Original Formula 8.7-9.2
Neutrogena Fresh Foaming Cleanser 6.2-6.9
Liquid Neutrogena 8.7-9.1
Neutrogena Pore Refining Cleanser 3.7-4.2
Neutrogena Cleansing Bar for Acne-Prone Skin 8.7-9.2
Neutrogena Oil-Free Acne Wash 3.6-4.4
Neutrogena Oil-Free Acne Wash Cream Cleanser 3.6-4.4
Neutrogena Oil-Free Acne Wash Foam Cleanser 3.5-4.2
Nutribiotic Non-soap skin cleansers 5.3-5.7
Olay Foaming Face Wash - 6.85-7.36
Olay Foaming Face Wash - Sensitive Skin 6.6 - 7.35
Olay Emollient Cleansing Lotion 6.0 - 7.2
Olay ADS Daily Renewal Cleanser 2.9 - 3.25
Olay ProVital Revitalizing Cleanser 2.9 - 3.25
Olay Daily Facials Normal/Dry 6.9 (when wet)
Olay Daily Facials Normal/Oily 7.6 (when wet)
Palmolive soap 10
Paula’s Choice (all formulations) 5.5
Physician's Choice pHaze1: Facial Wash 5%AHA 6
Physician's Choice pHaze1: Facial Wash oily/problem 7%AHA 5
Purpose Facial Cleanser 6.5-7.0>


Anonymous said...

i had this smell for the past 15 years and finally stomped on the idea of sqatting for every bowel movement will get rid of odor in about two weeks. reason being is that the smell TMAU is also made up of feces, bacteria and gas. We are so backup with feces. The less you have in the colon, the less smell builds up so the less odor. When you squat to move your bowels you have a complete evacuation leaving less odor. It will take about two weeks to move out all the old feces when you start practicing this procedure. A colonic cleanse will speed up this process providing you purchase a squatting tool device to use with your toilet. Until you buy this product a bedpan will do the trick. Use the bedpan on the floor. Also take a probotic supplemtns. And please do your research on the Benefits of squatting when moving the bowels.

Apr 6, 2012, 5:22:00 PM
Anonymous said...

I have this issue but it only affects me in the summer or anytime the sun hits my skin. It is extremely embarassing I wish I could speak with someone who has this also for moral support. It is destroying my social life.

Jun 14, 2012, 12:55:00 PM
Anonymous said...

I have this issue and started a year ago. I have isolated myself. I stopped going out, can't make new friends. No one wants to talk to someone that smells, even at church. It's weird that my friends and family don't smell it. The smell is not constant, but when I'm in high stress, the smell triggers, well that's when I'm able to smell it. The smell permeates a whole auditorium (church) My smell ranges from rotten, sewage, and fecal. I've changed my food intake and wash in low pH soaps and take the recommended vitamins and it seems to work. The foods I still struggle with, it's mostly trial and error.

Dec 29, 2012, 10:48:00 PM
Anonymous said...

Is TMAU considered to be a food intolerance disease?

Apr 18, 2013, 1:29:00 AM
blogcontributor2 said...

In a way it could be called that in the sense the person (with genetic TMAU) cannot efficiently break down trimethylaine, but it's not an 'allergy' reaction (e.g. immune reaction). It's a mismatch between the amount of trimethylamine and the ability to oxidize it all.

It's mainly a diet to avoid trimethylamine, and anything that may inhibit the enzyme that oxidizes trimethylamine.

The idea is to avoid trimethylamine., For instance choline is broken down to trimethylamine by gut bacteria. This is probably the main source of trimethylamine in humans apart from seafood

And also to avoid anything that may inhibit the FMO3 enzyme (such as cruciferous vegetables).

I guess 'intolerance' usually means because they cannot break something down normally and tend to become overloaded with a compound (such as lactose), but it is not an immune reaction.

Apr 18, 2013, 1:55:00 AM
Anonymous said...

Imused to smell so bad. It turn out the regular soap was the culprit because it made my skin too alkaline. After hours of research , I switched to low ph soap.amazing result. I have no body odor even after working out. My sweat is odorless.i hope this help someone

Aug 9, 2014, 12:17:00 AM
Anonymous said...

i suffer .. someone help me

Jul 4, 2020, 4:00:00 AM
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