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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Tuesday, December 16, 2008

Can you test gut candidiasis with an alcohol breathalyzer ?

A specialising lab in the UK, Biolab, believes that yeast is the most likely producer of ethanol from sugar in the gut, and so they have designed their gut candidiasis test based on this. They give you a sugar-challenge and then test your blood for ethanol levels (as well as other alcohols, that are thought to be produced by bacterias). Their test is primed to test you for small intestine fungal overgrowth, the first blood sample drawn an hour after glucose ingestion as the glucose capsule has not had time to reach the colon by then.

http://www.biolab.co.uk/gutferm.html

Excessive growth of Candida in the small intestine results in the production of ethanol from ingested dietary carbohydrate. The alcohol thus produced passes into the blood. The exact identity of the fungus involved is still open to question, but the assumption is that it is the growth of either Candida or another yeast that causes the symptoms...

...Increased ethanol with no methanol and only slight increases in other alcohols suggests yeast overgrowth. Increased ethanol with some methanol present and only slight increases in other alcohols suggests that there may have been ingestion of alcohol in the 24 hours prior to the test. An increase in a range of alcohols, but not ethanol, suggests a bacterial dysbiosis in the small intestine, possibly due to malabsorption. Similarly raised levels of short chain fatty acids, with normal or nearly-normal blood alcohols, suggests increased bacterial fermentation in the colon, probably secondary to mild small intestinal malabsorption.

http://www.biolab.co.uk/docs/gfp.pdf
This poses the question; if the theory is correct, can an ordinary 'alcohol breathalyzer' detect gut yeast overgrowth, since it actually tests for ethanol (alcohol being the common term used for ethanol in beverages) ?

The answer seems to be no. The levels of 'ethanol' Biolab are testing for are 100-1000 times less than the levels an ordinary breathalyzer test for. However, you can never be sure that someone with a bad candida problem may be close to 'over the limit'. It's unlikely, although there have been a few court cases claiming this defence. Some naturopaths have spoken of smelling a 'beery smell' from candida sufferers. So maybe it's worth buying the very cheap ($10) breathalyzers to see, under the premise you will always be 'nil', but it seems a waste of money to buy a decent breathalyzer.

other labs methods of detecting yeast metabolites in body fluids:
Metametrix use D-arabinitol as the marker for yeast fermentation status in their urine dysbiosis marker test.
Genova use Arabinose, Tartaric acid, and Citramalic acid. Metabolic Analysis Profile (Organic Acids)

related links:
Biolab abstract : Intestinal dysbosis, a review
Biolab abstract: Abnormal Gut Fermentation: Laboratory Studies Reveal Deficiency of B Vitamins, Zinc and Magnesium

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