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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Tuesday, December 16, 2008

1983 Paper: Profiles of Urinary Volatiles from 3 'odorous' Metabolic Disorders

Clinicians frequently associate peculiar body odors with a disease state, and for several disorders, such as trimethylaminuria, isovaleric acedemia, and maple syrup urine disease, "the odors are distinct enough to be diagnoses with a urine test using a gas chromatograph (GC)". See previous posts in this blog under the label: 'recognised metabolic odor conditions' for further reading on these metabolic disorders.

This 1983 article compares the profile of urinary volatiles from a healthy subject with those suffering from these metabolic disorders. The graphs on this paper clearly depict how the pathological profile was dominated by a few major components instead of the large number of minor components usually present in normal profiles. Yet, "Despite the apparent utility of an assessment of patient odor, little work has been done to define these diagnostic criteria..."

The volatiles profiles of patients suffering from this disorder [TMAU]were strikingly simple. A single large peak, usually the first peak to appear, Dominated the GC chromatogram. The compound eluting in this peak, identified as Trimethylamine by GC-MS, was present at such high amounts that in the short time required to saturate the collection trap, no other compounds were extracted to detectable quantities. Figure 6 is typical of the profiles obtained from a number of such patients...Contrary to earlier reports (13), we have found trimethylaminuria to be relatively frequent. In this laboratory over a period of about three years, 10 patients have been confirmed as suffering from this disorder, and we are aware that a similar number has been seen in other laboratories (D. M. Danks, personal communications). We will publish the results of a detailed investigation of this disorder in the near future.
full paper (PDF):


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