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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country
MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
rareconnect.org TMAU

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Blog Archive

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Tuesday, December 16, 2008

1983 Paper: Profiles of Urinary Volatiles from 3 'odorous' Metabolic Disorders

Clinicians frequently associate peculiar body odors with a disease state, and for several disorders, such as trimethylaminuria, isovaleric acedemia, and maple syrup urine disease, "the odors are distinct enough to be diagnoses with a urine test using a gas chromatograph (GC)". See previous posts in this blog under the label: 'recognised metabolic odor conditions' for further reading on these metabolic disorders.

This 1983 article compares the profile of urinary volatiles from a healthy subject with those suffering from these metabolic disorders. The graphs on this paper clearly depict how the pathological profile was dominated by a few major components instead of the large number of minor components usually present in normal profiles. Yet, "Despite the apparent utility of an assessment of patient odor, little work has been done to define these diagnostic criteria..."

The volatiles profiles of patients suffering from this disorder [TMAU]were strikingly simple. A single large peak, usually the first peak to appear, Dominated the GC chromatogram. The compound eluting in this peak, identified as Trimethylamine by GC-MS, was present at such high amounts that in the short time required to saturate the collection trap, no other compounds were extracted to detectable quantities. Figure 6 is typical of the profiles obtained from a number of such patients...Contrary to earlier reports (13), we have found trimethylaminuria to be relatively frequent. In this laboratory over a period of about three years, 10 patients have been confirmed as suffering from this disorder, and we are aware that a similar number has been seen in other laboratories (D. M. Danks, personal communications). We will publish the results of a detailed investigation of this disorder in the near future.
abstract: http://www.clinchem.org/cgi/content/abstract/29/10/1834?
full paper (PDF): http://www.clinchem.org/cgi/reprint/29/10/1834.pdf

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