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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Monday, December 22, 2008

Recent Monell Institute paper : Odor ID in mice not disguised by diet

Scientists from the Monell Center present behavioral and chemical findings to reveal that an individual's underlying 'odor signature' remains detectable even in the face of major dietary changes. The findings indicate that biologically-based odorprints, like fingerprints, could be a reliable way to identify individual humans.
This recent research paper from the Monell Institute at first glance seems to raise more questions than answers for metabolic body odor and halitosis sufferers, under the premise we hope the smells we are known for aren't our 'signature' smells. It wouldn't seem so, since it's very unlikely there's any advantage in having such a signature as fecal body odor :) . The signature seems to be mainly to do with odors associated with the Major Histocompatibility Complex, a cluster of genes important to immune system integrity and identity. Usually the olfactory cues in that case are looking for odor differences.

It is interesting that they mention how strongly diet can influence odortypes. This is generally accepted regarding different cultures and their diets, although presumably no culture accepts fecal body odor. Presumably they mean people can smell of the diet (for instance eating a curry), and also the odors from microbes feeding off the diet and resulting metabolites, but again fecal body odor and trimethylaminuria are unlikely part of the equation. They likely mean at very subtle, or undetectable, or desensitized levels. Metabolic body odor is likely a different ball game altogether. The sad part seems to be that they accept diet can make people smell all of all sorts of smells, but the only test for sufferers on offer is the trimethylamine test. The test used for these mice would seem much more preferable (i.e. a blank slate)

Also of interest is how many chemicals from their environment was in their urine. Full Paper: Genetically-Based Olfactory Signatures Persist Despite Dietary Variation



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