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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, December 22, 2008

Recent Monell Institute paper : Odor ID in mice not disguised by diet

Scientists from the Monell Center present behavioral and chemical findings to reveal that an individual's underlying 'odor signature' remains detectable even in the face of major dietary changes. The findings indicate that biologically-based odorprints, like fingerprints, could be a reliable way to identify individual humans.
This recent research paper from the Monell Institute at first glance seems to raise more questions than answers for metabolic body odor and halitosis sufferers, under the premise we hope the smells we are known for aren't our 'signature' smells. It wouldn't seem so, since it's very unlikely there's any advantage in having such a signature as fecal body odor :) . The signature seems to be mainly to do with odors associated with the Major Histocompatibility Complex, a cluster of genes important to immune system integrity and identity. Usually the olfactory cues in that case are looking for odor differences.

It is interesting that they mention how strongly diet can influence odortypes. This is generally accepted regarding different cultures and their diets, although presumably no culture accepts fecal body odor. Presumably they mean people can smell of the diet (for instance eating a curry), and also the odors from microbes feeding off the diet and resulting metabolites, but again fecal body odor and trimethylaminuria are unlikely part of the equation. They likely mean at very subtle, or undetectable, or desensitized levels. Metabolic body odor is likely a different ball game altogether. The sad part seems to be that they accept diet can make people smell all of all sorts of smells, but the only test for sufferers on offer is the trimethylamine test. The test used for these mice would seem much more preferable (i.e. a blank slate)

Also of interest is how many chemicals from their environment was in their urine. Full Paper: Genetically-Based Olfactory Signatures Persist Despite Dietary Variation



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