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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, January 26, 2009

2003 paper: Biofilms and the tongue: therapeutical approaches for the control of halitosis

2003 paper:

Biofilms and the tongue: therapeutical approaches for the control of halitosis.

Roldán S, Herrera D, Sanz M.

Faculty of Odontology, University Complutense, Plaza. Ramón y Cajal s/n, 28040, Madrid, Spain.

Methanethiol (also known as methyl mercaptan) is a colorless gas with a smell like rotten cabbage . It is a natural substance found in the blood , brain, and other animal as well as plant tissues... It is also one of the main chemicals responsible for bad breath and the smell of flatus. The chemical formula for methanethiol is CH3SH ; it is classified as a thiol.
Wikipedia
The dorsum of the tongue seems to harbour one of the most complex microbial niches in human ecology, sometimes resulting in halitosis. One of the main chemicals responsible for bad breath and the smell of flatus is methanethiol (also known as methyl mercaptan).

In addition to diagnosing and managing possible metabolic condition causing alveolar halitosis, one would also need to address the need to control this bacterial niche. Different home remedies that some sufferers claim have shown positive results include the use of a tongue scraper, applying drops of lemon juice toward the back of the tongue, gargling with a mild saline solution with baking soda, and nasal wash with a Neti Pot, amongst others. The following study explores the effects of various antimicrobial agents.

...little is known about how to control this bacterial niche, and factors affecting tongue coating composition and aspect are not fully understood. Studies available on the influence of mechanical or antimicrobial approaches against tongue biofilm are very limited. Mechanical treatments showed a transient reduction in halitosis-related variables but were limited in time. Different antimicrobials agents have been evaluated: chlorhexidine, chlorine dioxide, metal ions, triclosan, formulations containing essential oils , and hydrogen peroxide. However, most studies were designed as short-term models. Some of these studies demonstrated that the reduction in halitosis-related variables was associated with significant changes in the tongue microflora.

Abstract on springerlink.com

Wikipedia : Methanethiol

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