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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Friday, February 13, 2009

1983 review paper: The Diagnostic Potential of Breath Analysis

Approximately 200 compounds have been detected in human breath, some of which have been correlated to various diseases. With the advent of new technology that may permit the rapid analysis of breath, further progress can be anticipated in the use of breath metabolites for the diagnosis of disease, including neonatal screening, toxicology, and metabolic disease.
This 1983 paper is of interest mainly because of it's lists (which may or may not be outdated), demonstrating the potential of detecting compounds through breath. Particularly from alveolar breath, which is breath from the lungs that is being exhaled from the system. Such as the way breathalyzers detect alcohol. The lists demonstrate the authors thoughts on potential compounds that could be detected at the time. Trimethylamine gets a brief mention.

Breath analyzers certainly seem a potentially useful tool in diagnosing systemic body odor and both types of halitosis. Perhaps someday there may even be portable breathalyzers for the detection of compounds such as trimethylamine, so that sufferers can monitor their trimethylamine levels. Or trimethylamine test papers so that urine can be easily tested. Perhaps this sort of technology is already out there but they don't realise there is a market.

The metabolites excreted in the breath may be divided into five groups:

1. Lipid degradation products: Numerous diseases will affect the concentration of total serum fatty acid or the fatty acid chromatographic pattern in the breath. Breath acetone has already been shown to be useful in monitoring diabetes(13).
2. Aromatic compounds: Toluene and other alkylbenzenes, furan, naphthalene, and p-tolualdehyde have been detected in the breath (9-11). The origin of these compounds in the breath is generally not known.
3. Thio compounds: Methanethiol, ethanethiol, dimethylsulfides, and, in smaller concentrations, higher alkanethiol and alkylsulfides are present in human breath (9-11). Increased concentrations of specific thio-compounds have already been shown to have diagnostic significance in cirrhosis(14, 15) and ovulation (16).
4. Ammonia and amines: Ammonia would be expected to be increased in hepatic disease (although serum ammonia does not correlate well with hepatic coma) (17). Dimethylamine and triethylamine are increased in uremia (18).
5. Halogenated compounds: These are probably derived from inhaled, injected, or absorbed environmental pollutants and are of interest in industrial toxicology (8).


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