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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU UK end total:262
TMAU UK ends 23/01/20
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USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
click to read more
more details : karen.james@meboresearch.org

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Wednesday, March 11, 2009

Methanogens versus the sulfate-reducers in the colon

1993: Role of dietary sulphate in the regulation of methanogenesis in the human large intestine
Christl SU, Gibson GR, Cummings JH
MRC Dunn Clinical Nutrition Centre, Cambridge

1994: Methanogens outcompete sulphate reducing bacteria for H2 in the human colon
Strocchi A, Furne J, Ellis C, Levitt MD.
Minneapolis VA Medical Center, MN 55417

It's not known if the methanogen/sulfate reducing 'war' would have any significance in a body odor problem such as fecal body odor. Some feel they can smell of rotten egg, especially after eating high sulfur food, which makes you wonder if they are obvious 'sulfate-reducer dominant' (sulfide-producing dominant) in their colon (the sulfate/sulfur being changed to hydrogen sulfide by the sulfate reducing bacteria).

The current thinking is that either methanogens or sulfate-reducing bacteria are present in the colon. People are either dominant in one or the other. They are supposedly incompatible. Both compete for available hydrogen. Two well known departments in mainstream medicine are those run by MD Levitt in Minneapolis USA, and that by Glenn Gibson in the UK (now at Reading University). Both depts seem to have come to the conclusion that both bacteria compete and that people are dominant either in one or the other.

It would be interesting if a study was ever done regarding this and fecal body odor. Perhaps all would be 'sulfate-reducing bacteria dominant', since rotten egg seems to be a common smell. Methane is seemingly odorless. A skim-read of google searches on methane suggest it may be the reason that some can do 'flame-thrower' farts (using a lighter). It is not recommended trying this at home!

Checking for methane in the 'small intestine bacteria overgrowth' breath test was added probably because of such research as above. This breath test check for hydrogen levels, but they now know that methanogens use up hydrogen too. So they wanted to make sure the lack of hydrogen was not caused by methanogens 'eating' all the hydrogen.

You would think it may be wise to add sulfide in their breath tests, since these seem to consume hydrogen as well. Sulfate reducing bacteria produce sulfide. Perhaps it may even turnout that someday methanogenic bacteria are a good probiotic, although there has been some negative research on methanogens (e.g. one paper where methanogens were associated with constipation). Currently it is not known what significance methanogens or sulfide-producing play in the colon.


Related links:
About the small intestine hydrogen breath test

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