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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Thursday, March 12, 2009

2008 paper : Stephen Mitchell on FMO enzyme

Mitchell SC.
Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington, London.

http://www.ncbi.nlm.nih.gov/pubmed/18473746

Whilst the scientific community was celebrating the truly momentous discovery of a 'mixed function oxidase' another oxidase was quietly working behind the scenes, mopping up soft nucleophiles and, as it had undoubtedly being doing for aeons, aiding then unknown in the metabolism of xenobiotics and the protection of life forms. This enzyme, flavin mono-oxygenase, has subsequently been shown to be a major player, if not yet an equal partner with cytochrome(s) P450, in the metabolism of both endogenous biochemicals and foreign compounds that enter the human organism. This article outlines the importance of the flavin mono-oxygenases and examines their susceptibility to activity modulation by exogenous factors...
This would be an interesting read but sadly is not available free. It would likely make a good paper to show experts, who are likely very aware of the Cytochrome P450 group of oxidizing enzymes, but not the FMO group (which is currently recognised as being the 'trimethylaminuria causing' enzyme, but may turn out to be the 'generally smelly' enzyme, since it deals with sulfides and amines in particular).

Dr Mitchell has been responsible for many of the TMAU/FMO3 papers, and seems instrumental in instigating the first (international) TMAU workshop in 1999. It looks as if it was him who was the expert in the BBC documentary on TMAU (who the young boy visited). However he should be regarded as an FMO/TMAU expert and most of his TMAU work was done some years back. He also does work in many other areas of academic research. It's probably best to look elsewhere for expert contacts regarding fecal body odor and TMAU and other systemic body odors. Possibly those experts involved in healthcare may be more likely contacts.

Correction: the Dr in the BBC TMAU documentary was in fact Dr. Chris Hendriksz of the Birmingham Childrens Hospital

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