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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Saturday, July 25, 2009

Dimethylglycine dehydrogenase enzyme (DMGDH)

dmgdhd is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase.

Pathway: choline metabolism
Trimethylaminuria is the only real 'accepted' form of metabolic body odor by those few in the medical system who are aware of any form, but another often forgotten about is dimethylglycinuria, to do with saturation of the Dimethylglycine dehydrogenase enzyme. However there seems to be only one recorded case of DMGU, and it's unclear if this is because no-one tests for it or it is so rare.
(2001 dimethylglycinuria case)

There are a lot of similarities with 'official' TMAU, in that it is thought to give off a fish smell. Also the enzyme is part of the choline metabolism. That said, presumably this enzyme deals only with one 'substrate' (it oxidizes dimethylglycine), whereas FMO3 oxidizes 1,000s of substrates (including trimethylamine). The sufferer was also said to have a high creatine kinase blood level, which may be a clue as to this problem (or maybe not). Whilst FMO3 uses riboflavin as a co-factor, DMGDH uses folate as it's co-factor.

It would be interesting to know if they discovered DMGu by using an open-ended look for volatile organic compounds in a mass spectrometer/gas chromatography test, or if they were only looking for DMG. The former would be the best starting test for defining a metabolic body odor problem, since in most cases we don't know what we are looking for yet.

Why only one case has been recorded is not known, however it would seem at the moment that an assumption could be made that DMGu is very rare and that one or more other forms of metabolic body odor are far more common.

Dimethylglycine dehydrogenase is a gene that encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.

...defects in dmgdh are the cause of dmgdh deficiency (dmgdhd) [mim:605850]. dmgdhd is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. biochemically it is characterized by an increase of n,n- dimethylglycine (dmg) in serum and urine.

Biochemically it is characterized by an increase of N,N-dimethylglycine (DMG) in serum and urine.

Pathway: Amine and polyamine degradation; betaine degradation; sarcosine from betaine...

SwissProt Accession No.: Q9UI17 Dimethylglycine dehydrogenase, mitochondrial precursor; (Homo sapiens); 99% similarity over 866 a.a.

(Last modified July 7, 2009. Version 80.)


Jeanne said...

Are there any clinical trial for DMGDH? I understand there may be a pill coming out to help with TMAU, would that also work for DMGDH? I have the DMGDH gene, it has been 22 years of constant Dr. visits with no help from anyone - I am at the end of my rope, hope is running out. I have no life.

Aug 15, 2016, 11:44:00 AM
Anonymous said...

Are there any clinical trials pending for DMGDH? I understand there may be a pill coming out to help with TMAU, would this also help DMGDH? I have the DMGDH gene and have suffered for 22 years, hope is running out, I have no life.

Aug 15, 2016, 11:46:00 AM
blogcontributor2 said...

Hi. I don't know to be honest. Perhaps the tmau pill will alter the gut flora including microbes that produce DMG. But I really don't know.

I have known someone diagnosed DMGU before (the UK lab often tests tma-negative samples and as far as I know none have been found). I guess you have been diagnosed by the DNA test.

Aug 15, 2016, 12:01:00 PM
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