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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Saturday, October 17, 2009

Bloodborne body odor & halitosis : asparagus urine test experiment

It has been mentioned here before, that asparagus is known to make some people's urine smelly, but others not. However it is not widely known that there seems to be a 3rd category where the person is unable to smell smelly asparagus urine. Since it is a 'trivial' problem, probably not enough research has went into finding out all the categories and the reasons. But given the compounds thought likely to cause 'asparagusuria' (sulfides etc), it was thought it may be interesting to find out what the 'pattern' is amongst systemic body odor and halitosis readers may be. For instance, it may turn out to be a way of telling whether people are 'FMO3-vulnerable' or not. Or it may not.

Research into 'asparagusuria' has been very limited, and the few papers done can give conflicting outcomes. For the purpose of this post, it will be assumed that the work of Mitchell is the most convincing, since he has done the most extensive research.
Mitchell 2001 summary about asparagusuria
1987 study : Odorous urine following asparagus ingestion in man.

It appears that people may fall into the following categories :

excretor (of smelly asparagus urine) or non-excretor
perceiver (can smell smelly asparagus urine) or non-perceiver

So there are 4 categories people can fit into. For example, someone can have smelly asparagus urine and not perceive it, while someone else can have non-smelly urine and can perceive smelly urine. The excretion part is about whether the person has unmetabolized smelly asparagus compounds in their urine. The 'perceiver' part is about the persons abilty to smell such compounds in urine. Of a study Mitchell was involved in in 1987, of the 800 volunteers, about 43% were 'excretors', and a much smaller amount excretors of very 'potent' smelling urine.

Since smelly compounds are involved, it was thought it may be worth doing a 'snap' poll of our own urine after asparagus consumption, especially since many cannot smell themselves (non-perceivers). A poll is also set up for family/partners as an anecdotal experiment, although the whole experient has the possiblity of 'non-perceiver' over it, since we don't know now for sure if we couldn't smell it or it didn't smell. Not unless you get a known 'perceiver' to smell it !

And so, onto the rules of the study
Asparagus urine test :
eat at least 5 sticks of asparagus (in a meal will do)
sniff urine over the next 12 hours. Especially the next 'batch' of urine after asparagus consumption.

The polls can be read below

Bloodborne body odor : If someone else smelt your urine, could they smell anything ?

Bloodborne body odor : Did your urine smell after asparagus consumption ?

Bloodborne halitosis : If someone else smelt your urine, could they smell anything ?

Bloodborne halitosis : Did your urine smell after asparagus consumption ?

2 comments: said...

Very interesting poll, most publications say, that the urine of almost 50% does not smell

Feb 27, 2010, 12:45:00 PM
Maria de la Torre, Founder and Executive Director, MEBO Research said...

Urea in urine is odorless, however bacteria usually increases the pH as they break down urea to ammonia. A diet high in citrus fruits, vegetables, or dairy products can increase your urine pH (alkaline). A diet high in meat products or cranberries can decrease your urine pH (more acidic). There are many factors that affect odor in the urine.

Feb 27, 2010, 1:33:00 PM
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