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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Sunday, October 25, 2009

First tester's results in the MeBO-Biolab Gut Dysbiosis in systemic body odor and halitosis study

The first volunteer for the MeBO-Biolab gut dysbiosis study has completed his tests. The study is intended to look at various aspects of 'gut dysbiosis' in relation to metabolic body odors and halitosis, to see if there are any patterns.

These were the results of the first tester :

Gender : Male, 30s
Odor type: Had a fecal halitosis problem for many years and feels it is systemic based

Tests done:

  • Gut fermentation test : normal (according to Biolab)
  • Indicans : normal
  • D-lactate blood test : normal
  • Gut permeability : some malabsorption of the smaller sized molecules. Did not have 'leaky gut'
The tests were chosen to examine various aspects of 'gut dysbiosis' (though not all). The gut fermentation test is regarded as being reliable for testing candida overgrowth in the small intestine (using ethanol as the marker). It also tests for other alcohols and fatty acids associated with bacterial dysbiosis. The gut permeability test examines the persons absorption ability, as well as testing for 'leaky gut' (hyper-permeability).The d-lactate test was chosen because a recent chronic fatigue paper suggested that d-lactate acidosis may be implicated in many chronic fatigue cases. It is also hypothesized that a bi-product of this could be hydrogen sulfide production. The indicans test is an inexpensive test associated with protein putrefaction by bacteria.

The first testers results seemed to be mostly normal apart from some 'hypo permeability', which is decreased absorption of some smaller sized molecules. At the moment, we could not suggest what this could be, except a slight malabsorption issue. This is the opposite of 'leaky gut', in which case, molecules would be too large get through the gut semi-permeable wall.

The 2nd volunteer is now testing, the 3rd will start soon, and others interested are welcomed to volunteer if they wish.

The expert that is kindly helping us, Dr. Irene Gabashvili, has sent these comments about the results to the tester. Each tester will also receive such comments from her based on their test results.
As you know, your results are opposite of a leaky gut - decreased and not increased permeability as compared to healthy individuals. Your intestinal permeability is not decreased too much though, so these are just a few pointers:

Lining of the intestines has a few relatively large pores and many small pores letting small molecules to pass through. Leaky gut means more large holes in the gut that let larger molecules to enter the blood stream before they are broken down into "edible pieces". In some other conditions, the number of small pores and entire intestinal surface area gets reduced - tightening the gut and slowing down the normal flow, decreasing intestinal permeability and causing malabsorption.

Sometimes decreased permeability is because of vegetarian diet, fasting or smoking.

I believe, MEBO community will benefit from better understanding of
diets and symptoms - I hope to develop an anonymous web tool for easy
logging and interpreting the data. Any suggestions would be

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What MeBO is doing

About privacy:
see Donate page

Currently raised:
173.50 GBP = 275.84 USD
MeBO is continuing with this line of study, and anyone is welcome to participate. Unfortunately, each participant would need to pay for the tests themselves, which in total would be £146 if all tests are chosen by the tester. MeBO will collate the non-personal data and look for a pattern from amongst all testers under the direction of Dr. Irene Gabashvili.

MeBO hopes to continue such tests and aspires to become a charity. As a charity, MeBO can then pursue grants and endowments in order to carry out large-scale international studies. Anyone wishing to donate to MeBO's aims to further support this and other studies could do so using the PayPal button in this post and in MeBO's website. Your support would be greatly appreciated by anyone suffering from a body odor condition who is looking for answers.

Anyone who would like to be part of the study could do so by filling out the MeBO-Biolab gut dysbiosis in body odor or halitosis study form-REVISED.
Or you can contact Maria by email at


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