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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU UK end total:262
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Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
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Return cut-off date : passed
Analysis can take 6/8 weeks
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

https://www.meboblog.com/2023/01/denver-tmau-test-survey-tbc-who-it-is.html

Thursday, October 22, 2009

Researchers compare the portable sulphur monitors Halimeter and OralChroma in halitosis cases

A team of researchers from Belgium have recently published a research paper on the use of the halimeter (by Interscan) and oralchroma (by abilit) as halitosis measuring devices on a large number of people claiming to have halitosis. The department they are from has a background in halitosis research.

2009 paper : Clinical reliability of non-organoleptic oral malodour measurements

Vandekerckhove B, Van den Velde S, De Smit M, Dadamio J, Teughels W, Van Tornout M, Quirynen M.

Department of Periodontology, Catholic University of Leuven, Leuven, Belgium.

Aim: Measurement of volatile sulphur compounds (VSC) by portable sulphur monitors (Halimeter((R)), OralChroma()) is a common practice for diagnosis of oral malodour. In this study, the clinical value of these devices was examined. Materials and Methods: Two hundred and eighty patients with bad breath complaints attending a halitosis consultation were enrolled. Organoleptic scores were given by a trained and calibrated judge, before measurement of the VSC levels (Halimeter((R)), OralChroma()), to avoid any bias. Results: Significant correlations were found between the organoleptic assessment, the Halimeter((R)), and the OralChroma() (R=0.74 for organoleptic versus Halimeter((R)); 0.66 for organoleptic versus OralChroma(); 0.63 for Halimeter((R))versus OralChroma()). The sensitivity and specificity (with regard to the organoleptic score) to detect patients with/without oral malodour for the Halimeter((R)) were 63% and 98%, respectively, and for the OralChroma() 69% and 100% when using the cutoffs suggested by the manufacturer. By lowering these values, sensitivity could be improved without a significant decrease in specificity (both devices). Conclusions: We concluded that the measurement of the VSC levels can be used as an adjunct to the organoleptic assessment. Thresholds should be revisited in order to improve their clinical utility. These devices can prove the absence of malodour in case of pseudo-halitosis.

Related links :
Van den Velde pubmed papers

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