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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, November 20, 2009

MeBO-Biolab body odor gut dysbiosis study : An elaboration of tester 2's results

Tester 2
Odor problem:
Systemic body odor between 10-20 years.
Gut problems
Other problems
Thrush, vaginal, Allergies, Headaches, cystitis, and urinary tract infections on eating certain foods
Results :
Tester 2
Gut FermentationEthanol raised (140 : normal is less than 22). Some other 'bad' bacteria alcohols raised but no comment made by lab. Butyrate (good SCFA) lowish

Gut permeability slight increase in permeability for mid-sized molecules

Indicans Negative
D-lactate 156 (normal is below 60)

MeBO Research is currently carrying out a Gut Dysbiosis Study in cases of body odor and halitosis, with the help of Biolab Medical Unit in London.

Recently, tester 2's results were received and showed some interesting patterns, as can be seen in the previous post, '2nd tester's results in the MeBO-Biolab Gut Dysbiosis in metabolic body odor and halitosis study'. This post will be an elaboration of the abnormal results.

The 2nd tester is a lady in her 50s who describes herself as having a sewage/garbage/rotten cabbage/sulfur/damp/dirty odor condition, which she has had for 10-20 years. She believes it is systemic. She has fungal issues, as well as issues with allergies/headaches, cystitis, and constipation. Her TMAU results were negative, including the DNA test.

Analysis of her results :

Plasma D-lactate Elevated…thought to be only sourced from fermentation by lactic acid bacteria in the digestive tract, usually the small intestine… linked to Chronic Fatigue Syndrome…Plasma D-lactate : ELEVATED more than double the maximum normal range.- Tester 2's D-lactate was raised, implying an abnormally high amount of D-lactate in the blood. D-lactate in humans is thought to be only sourced from fermentation by lactic acid bacteria in the digestive tract, usually the small intestine. D-lactate is not the same type of lactic acid that our muscles create when tired, which is known as L-lactate. L-lactate is very easily metabolized, whereas D-lactate is not, and a build up can cause D-lactic acidosis. Lactic acid bacteria normally reside in the lower half of the small intestine of a healthy person. Currently, the only people expected to potentially have problems with D-lactic acidosis are people with a shortened small intestine.

D-lactate is also of interest because recently a Chronic Fatigue Syndrome theory was put forward where the reason for the fatigue was given as excess hydrogen sulfide, which was deemed to have been produced by lactic acid bacteria. However, this theory is new and not proven anywhere else. It should be noted that probiotics with lactic acid bacteria would be likely to worsen things if someone is producing too much D-lactic acid already, so lactobacillis acidophilus and other LAB would be best avoided in this case.

Gut Fermentation Profile results: Raised ethanol fermentation consistent with yeast overgrowth... Gut Fermentation Profile results : RAISED ETHANOL FERMENTATION CONSISTENT WITH YEAST OVERGROWTH. Over six time higher than highest normal range. Some of the tester's other alcohols were also slightly raised, which are associated with bad bacteria. Note: A glucose load was given one hour before sampling. All results assume 24 hours without alcohol ingestion and three to twelve hours fasting.
Tester 2's gut fermentation results were probably typical of many gut dysbiosis results, in that they were high for ethanol and low for some of the good fatty acids, such as Acetate, Propionate, Butyrate, produced by good bacteria. Biolab uses ethanol as the biomarker for candida over-production in the small intestine, since they point out that ethanol is only known to be produced by yeast in humans.

Intestinal Permeability Profile
using polyethylene glycol (PEG400) : SLIGHT INCREASED PERMEABILITY TO PEG around mid-range absorption levels (between mwt 374 to 506). Tester 2's gut permeability was normal apart from being borderline over-permeable around the mid-range absorption level.

Urine Indicans : NORMAL
Tester 2's Indicans test was normal.

Summary : In summary, tester 2's results seem to mainly imply a yeast overgrowth in the gut, as well as an overgrowth of lactic acid bacteria. The permeability test was borderline at the midrange, and her short chain fatty acids from good bacteria were on the low side, as well as the alcohols from bad bacteria being slightly higher than wished. This does not say that the results have anything to do with her body odor problem, since many other factors have not been ruled out, and there is not enough data on the condition to arrive at a conclusion. Nevertheless, it is interesting since many people with 'bowel smells' body odor often have gut complaints.

The MeBO-Biolab gut dysbiosis study is still open for anyone wishing to test. Unfortunately, volunteers would need to pay his or own costs (a maximum of £146). It is aimed specifically at people with fecal/bowel smells body odor, but since the tester is paying, anyone with body odor or halitosis is welcome to test.

The form to test in MeBO-Biolab Gut Dysbiosis Study is here :
MeBO-Biolab gut dysbiosis in body odor or halitosis study form-REVISED

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About MeBO Research : MeBO Research aims to become a charity focusing on systemic body odor and systemic sourced halitosis, particularly 'bowel smells' body door, since it is the most common. Any donations are welcome to primarily reach MeBO's aim of charity status. As a charity, MeBO can then pursue grants and endowments in order to carry out large-scale international studies.


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