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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Tuesday, April 13, 2010

Differences between Trimethylaminuria urine testing at Arkansas CH and UC Denver

Arkansas Children's Hospital
is no longer performing the test for TMA, as per the
Supervisor, Clinical La/Metabolic Genetics, AKC
September 2013

Currently the only known Trimethylaminuria urine testing labs in the USA are :
Arkansas Children's Hospital, Metabolic Genetics Laboratory
University of Colorado Denver, Biochemical Genetics Lab
At this stage in the evolution of TMAU testing, there seems to be no agreed standard, and each testing lab sets their own testing procedures and reference range. This post attempts to clarify the differences between the 2 labs known to be TMAU testing in the USA.

The main differences seem to be :

Arkansas only tests for Trimethylamine levels, and is much cheaper (around $130)
Denver tests for trimethylamine and trimethylamine-oxide, but is dearer (around $250)

Since TMA-oxide is the final metabolized product of normal FMO3 function, it would seem best to test for TMA-oxide as well as a defining test. TMA-oxide gives you an idea of how well your FMO3 enzyme dealt with the TMA load, and therefore gives an indication as to the % function of the enzyme. It is not possible to get an idea if you have a genetically poor functioning FMO3 enzyme without testing TMA-oxide levels.

Apparently, The 2 labs also use different equipment for the TMAU urine test, although probably both are reliable.

Probably a best idea would be to use the Denver lab as a first choice, and perhaps use the Arkansas lab for monitoring TMA levels if price is a factor.

USA TMAU urine test labsArkansas Children's HospitalUniversity of Colorado, Denver
lab nameMetabolic Genetics LaboratoryBiochemical Genetics Laboratory
Official informationACH TMAU test requisition form (PDF)

Lab webpage
Lab webpage

More contact details for TMAU testing labs


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