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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
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at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

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want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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BO Sufferers Podcasts

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

https://www.meboblog.com/2023/01/denver-tmau-test-survey-tbc-who-it-is.html

Sunday, May 22, 2011

23andme.com DNA test not as thorough for FMO3 testing as hoped

In a previous post it was suggested that the 23andme.com DNA test may be a good way of DNA testing for FMO3 variants/mutants inexpensively. However, it seems that the number of FMO3 SNPs checked for is not as comprehensive as hoped. It checks for 56 FMO3 SNPs in total. Of those, only 17 are at codons with known variants/mutants. Most of the others seem to be to do with FMO3 introns (introns will be discussed in a later post) and about 5 are currently unlisted for any information.

It tests for 17 variants/mutants, out of about 50 known variants/mutants. Most of the 17 are common polymorphisms/variants, but the rarer more severe mutants are not checked for.

The variants, mutants tested for are at the codons listed below (an FMO3 protein is made up of 532 codons)

82, 147, 158 ,205
,239 ,257 ,277 ,285
,302 ,305 ,308 ,360
,362 ,486 ,502 ,503 ,510

This does not include the codons known to have rarer known variants/mutants (about 300 ?) such as at codon :

32, 37, 51, 52, 58, 61, 64,
66, 114, 143, 148, 153, 187
197, 198, 199, 201, 223, 237,
238, 314, 387, 388, 394, 415
434, 470, 475, 492, 500

So it looks like the 23andme.com genetic testing service is currently not suitable for FMO3 DNA testing other than for the more common FMO3 variants. It should be also kept in mind that much more is still to be learnt about FMO3 genetics, and even a comprehensive test is currently still capable of a 'false negative' result. For example, little is known of the FMO3 introns (all the testing and research mostly involving the exons), as explained in this post

23andme do update their SNP testing chip occasionally, so in future it is possible it will be more thorough for FMO3. But FMO3 seems a low priority to them so it is unlikely, and if you have already used their service you would need to retest


pubmed list of FMO3 SNP's

1 comments:

Debora said...

Hi, I read that 23andMe has changed technique, now they use the new Illumina GSA chip.
I haven't yet 250€ (only 100€, for the DNA test) for the urine test for Sheffield Hospital (and I also read that they are all giving negative results), it is useful to take a test of 23andMe DNA (Ancestry version, the base one)?
At least to start investigating if I can have the TMAU or not, after more than 20 years of bad smell.. :(

Feb 12, 2018, 10:03:00 AM
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