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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Sunday, May 22, 2011

23andme.com DNA test not as thorough for FMO3 testing as hoped

In a previous post it was suggested that the 23andme.com DNA test may be a good way of DNA testing for FMO3 variants/mutants inexpensively. However, it seems that the number of FMO3 SNPs checked for is not as comprehensive as hoped. It checks for 56 FMO3 SNPs in total. Of those, only 17 are at codons with known variants/mutants. Most of the others seem to be to do with FMO3 introns (introns will be discussed in a later post) and about 5 are currently unlisted for any information.

It tests for 17 variants/mutants, out of about 50 known variants/mutants. Most of the 17 are common polymorphisms/variants, but the rarer more severe mutants are not checked for.

The variants, mutants tested for are at the codons listed below (an FMO3 protein is made up of 532 codons)

82, 147, 158 ,205
,239 ,257 ,277 ,285
,302 ,305 ,308 ,360
,362 ,486 ,502 ,503 ,510

This does not include the codons known to have rarer known variants/mutants (about 300 ?) such as at codon :

32, 37, 51, 52, 58, 61, 64,
66, 114, 143, 148, 153, 187
197, 198, 199, 201, 223, 237,
238, 314, 387, 388, 394, 415
434, 470, 475, 492, 500

So it looks like the 23andme.com genetic testing service is currently not suitable for FMO3 DNA testing other than for the more common FMO3 variants. It should be also kept in mind that much more is still to be learnt about FMO3 genetics, and even a comprehensive test is currently still capable of a 'false negative' result. For example, little is known of the FMO3 introns (all the testing and research mostly involving the exons), as explained in this post

23andme do update their SNP testing chip occasionally, so in future it is possible it will be more thorough for FMO3. But FMO3 seems a low priority to them so it is unlikely, and if you have already used their service you would need to retest


pubmed list of FMO3 SNP's

1 comments:

Debora said...

Hi, I read that 23andMe has changed technique, now they use the new Illumina GSA chip.
I haven't yet 250€ (only 100€, for the DNA test) for the urine test for Sheffield Hospital (and I also read that they are all giving negative results), it is useful to take a test of 23andMe DNA (Ancestry version, the base one)?
At least to start investigating if I can have the TMAU or not, after more than 20 years of bad smell.. :(

Feb 12, 2018, 10:03:00 AM
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