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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed

Blog Archive

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Sunday, May 22, 2011

23andme.com DNA test not as thorough for FMO3 testing as hoped

In a previous post it was suggested that the 23andme.com DNA test may be a good way of DNA testing for FMO3 variants/mutants inexpensively. However, it seems that the number of FMO3 SNPs checked for is not as comprehensive as hoped. It checks for 56 FMO3 SNPs in total. Of those, only 17 are at codons with known variants/mutants. Most of the others seem to be to do with FMO3 introns (introns will be discussed in a later post) and about 5 are currently unlisted for any information.

It tests for 17 variants/mutants, out of about 50 known variants/mutants. Most of the 17 are common polymorphisms/variants, but the rarer more severe mutants are not checked for.

The variants, mutants tested for are at the codons listed below (an FMO3 protein is made up of 532 codons)

82, 147, 158 ,205
,239 ,257 ,277 ,285
,302 ,305 ,308 ,360
,362 ,486 ,502 ,503 ,510

This does not include the codons known to have rarer known variants/mutants (about 300 ?) such as at codon :

32, 37, 51, 52, 58, 61, 64,
66, 114, 143, 148, 153, 187
197, 198, 199, 201, 223, 237,
238, 314, 387, 388, 394, 415
434, 470, 475, 492, 500

So it looks like the 23andme.com genetic testing service is currently not suitable for FMO3 DNA testing other than for the more common FMO3 variants. It should be also kept in mind that much more is still to be learnt about FMO3 genetics, and even a comprehensive test is currently still capable of a 'false negative' result. For example, little is known of the FMO3 introns (all the testing and research mostly involving the exons), as explained in this post

23andme do update their SNP testing chip occasionally, so in future it is possible it will be more thorough for FMO3. But FMO3 seems a low priority to them so it is unlikely, and if you have already used their service you would need to retest


pubmed list of FMO3 SNP's

1 comments:

Debora said...

Hi, I read that 23andMe has changed technique, now they use the new Illumina GSA chip.
I haven't yet 250€ (only 100€, for the DNA test) for the urine test for Sheffield Hospital (and I also read that they are all giving negative results), it is useful to take a test of 23andMe DNA (Ancestry version, the base one)?
At least to start investigating if I can have the TMAU or not, after more than 20 years of bad smell.. :(

Feb 12, 2018, 10:03:00 AM
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