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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Wednesday, March 7, 2012

Odor originating from Metabolic Disorders


BO, Body Odor777.com, Causes of and Solutions for Body Odor, has a good list of some known metabolic body malodor disorders, including trimethylaminuria (TMAU), Hypermethioninemia (HME), Maple Syrup Urine Disease (MSUD), Phenylketunuria (PKU), Multiple Acyl-CoA Dehydrogenase Deficiency (MADD), Isovaleric Acidaemia, On the left sidebar, it lists internal causes, to name a few.

They define hypermethioninemia as,


Hypermethioninemia this condition can happen when methionine (amino acid) is not metabolized correctly in the body. Individuals with this condition may experience a fishy, sweety and fruity, rancid butter or boiled cabbage odor. It has been said that tyrosinosis-tyrosinemia is the same as hypermethioninemia.

Many if not most of the conditions noted in this list area considered serious diseases, and some are life threatening. We wonder if perhaps sufferers have elevated levels of one or more of the volatile organic compounds (VOCs), while still within the normal range; and the combination of these could possibly produce a strange odor that many describe, such as garbage, sewer, fecal, or burnt odor. This is what MEBO Research will attempt to study in the Alveolar Breath Research Study soon to be launched, as well as with our methionine test in London.

On the left sidebar of the BO777 site, they have an extensive list of internal causes of body odor. It is very possible that sufferers may have a combination of sources contributing to the difficulty in controlling symptoms.

What this site lacks are reference to published papers, so the reader is encouraged to do further research into these conditions from reliable, professional journals.

See other posts in this blog:
  1. Phenylketonuria and Maple Syrup Urine disease. Recognised bloodborne odor problems
  2. 1983 Paper: Profiles of Urinary Volatiles from 3 'odorous' Metabolic Disorders
María

María de la Torre
Founder and Executive Director

A Public Charity
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maria.delatorre@meboresearch.org
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