Most Frequently Asked Questions (FAQ) by sufferers, and some Answers (A)

Most frequently asked questions (FAQ)
by sufferers:

1. Where do I begin to find out what causes my odor/halitosis condition, and how can it be cured?
2. Do I have Primary TMAU (TMAU1)

?

Do I have Secondary TMAU (TMAU2)?

What about the 70+% who test negative for TMAU1 & TMAU2? What do they have?

Could a microbial imbalance in my gut be the cause of odor symptoms?

Could I have more than one FMO3 deficiency, which then would compromise multiple metabolic pathways resulting in an odorous chemical buildup in my body?

What about women’s needs – hormonal changes, vaginal microflora alterations possibly due to changes in pH in mucosal tissue and FMO3 deficiencies?

In an effort to find answers to these questions, sufferers are usually recommended to do the following:

1. Consult with your physician and/or dentist to rule out the already known causes of these symptoms.
2. When your physician cannot find a cause, the TMAU Test is recommended. If you decide to do your TMAU Test through MEBO, your urine sample will be analyzed with a High performance liquid chromatography (HPLC).

3. What would TMAU Test results performed by HPLC look like? See
   
   
   TMAU Test Results Chart

of 64 patients who have done the TMAU Test with HPCL. Please note that the three columns, TMA, TMAO, and TMA/TMAO RATIO, have been individually sorted from highest to lowest results, and therefore, reading across a row would not represent the results of any one particular patient.

Where would your figures fall in the 64 patient TMAU Test Results analyzed with HPLC? If you would like to get answers to some of these questions, you can fill out the

Requisition Form,

to obtain cost information of the test ($150) and shipping cost to/from your address. There would be no additional expense for your test experience after this initial payment - no additional fees or hidden costs.

How results are interpreted:

• TMAU1 can only be truly confirmed by FMO3 enzyme analysis (difficult because a liver biopsy would be needed) or DNA analysis.
• TMAU2 must be a diagnosis by exclusion.
• TMA-oxide can be used as a guide, but is not diagnostic for TMAU2.
• Therefore, if TMA is increased and TMA-oxide is normal and (as in many cases) FMO3 is not proven to be affected the diagnosis must be TMAU2 by exclusion.
• If TMA is normal and TMA-oxide is significantly high, suggest a re-test following a choline load.
  
  Nigel Manning, Principal Clinical Scientist
  Department of Metabolic Biochemistry at Sheffield Children's Hospital, UK

What if my results fall in the larger black area of the chart results (negative for TMAU1 & TMAU2)? As you can see, the majority of sufferers, approximately 70%, fall in the negative for Primary and Secondary TMAU combined category. In fact, 95% fall in the negative for Primary TMAU category.

This is a clear indication that a great deal of exploratory research needs to be carried out to discover other causes.

MEBO is committed to pursuing research, especially exploratory research, the type of studies that are merely formative, for the purpose of gaining new insights, discovering new ideas, and increasing knowledge into the various causes of uncontrollable body and breath odor conditions.

María

María de la Torre
Founder and Executive Director

A Public Charity
www.meboresearch.org
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maria.delatorre@meboresearch.org
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