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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Wednesday, November 27, 2013

New research paper on Isolated Persistent Hypermethioninemia

Paper title :  Spectrum of mutations associated with methionine adenosyltransferase I/III deficiency among individuals identified during newborn screening in Japan.

by : Nagao M, Tanaka T, Furujo M. Source Department of Pediatrics and Clinical research, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan

pubmed link to abstract :  isolated persistent hypermethioninemia research paper

It has been noted in the blog before that  isolated persistent hypermethioninemia (IPH) is another known cause of 'metabolic malodor'. There is not much interest in this as it is generally regarded as being 'benign' (i.e. symptomless) apart from a malodour (probably in a transient form).

Only the abstract is free to read, but from the abstract it seems this is a similar paper that geneticists tend to do about metabolic disorders, i.e. checking out a small group of 'sufferers' to check the gene at fault for the sufferers' variants/mutants etc. They estimate that in Japan the 'disorder' may affect about 10 in a million, but 'facts' of these disorders tends to start on the conservative side and tend to focus on 'severe' genetic types. So it is presumably unknown how many may have this disorder in a more 'genetically milder' 'transient' form.

They also claim in this paper that it may not be a 'benign' metabolic disorder (i.e. malodor is not important) as some in their group had  "brain demyelination or neurological complications"


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