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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Wednesday, November 27, 2013

New research paper on Isolated Persistent Hypermethioninemia

Paper title :  Spectrum of mutations associated with methionine adenosyltransferase I/III deficiency among individuals identified during newborn screening in Japan.

by : Nagao M, Tanaka T, Furujo M. Source Department of Pediatrics and Clinical research, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan

pubmed link to abstract :  isolated persistent hypermethioninemia research paper

It has been noted in the blog before that  isolated persistent hypermethioninemia (IPH) is another known cause of 'metabolic malodor'. There is not much interest in this as it is generally regarded as being 'benign' (i.e. symptomless) apart from a malodour (probably in a transient form).

Only the abstract is free to read, but from the abstract it seems this is a similar paper that geneticists tend to do about metabolic disorders, i.e. checking out a small group of 'sufferers' to check the gene at fault for the sufferers' variants/mutants etc. They estimate that in Japan the 'disorder' may affect about 10 in a million, but 'facts' of these disorders tends to start on the conservative side and tend to focus on 'severe' genetic types. So it is presumably unknown how many may have this disorder in a more 'genetically milder' 'transient' form.

They also claim in this paper that it may not be a 'benign' metabolic disorder (i.e. malodor is not important) as some in their group had  "brain demyelination or neurological complications"


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