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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Friday, December 6, 2013

Responses Summary Halitosis & Tonsillectomy


Please participate in the Halitosis Study Questionnaire #2 if you have not done so yet.


The more breath (malodor) halitosis sufferers participate in this questionnaire, the greater amount of data is consequently documented and compiled regarding this condition. Dr. Murat tells us in the paper he wrote for MEBO's 2013 Annual Meetup and Conference held in Memphis, TN, “How can we understand whether halitosis comes from mouth or breath?,” which describes the origin of Oral (malodor) Halitosis and Breath (malodor) Halitosis and the differences of their clinical signs.

In addition to making reference to the work done by Drs. Tangerman, Whittle, and Phillips, et al., his paper presents excerpts from his book, Halitosis, In: Oral Microbiology,
Aydin M. Aydin M. (2012). Halitosis. In: Oral Microbiology. Aydin M, Mısırlıgil A. editors. Ankara: MN Medical & Nobel, p.97-105.,

Breath (malodor) Halitosis, as opposed to Oral (malodor) Halitosis, comes from blood gases. Naturally volatile aromatic metabolites, usually by-products of biochemical processes, are present in the breath (Tangerman A, 2002). Exhaled molecules reflect the arterial concentrations of biological substances (Whittle at al., 2007). A total of 3,481 different VOC were observed in the breath of normal humans (Phillips et al., 1999). Many alcohols and aldehydes exhaled that have pungent odor begin to be offensive when they exceed a specific threshold.

Dr. Aydin has shown interest in our international community and has focused his study on the causes and treatment of the various types of halitosis. He gives an explanation below listing some of the compounds released in the breath,

In the breath of healthy persons, ammonia, acetone, methanol, ethanol, isoprene,
propanol, acetaldehyde, C13-20 alkanes, and hydrogen were measured as 833, 477,
461, 112, 106, 18, 22 ppb, 1.5 x10 -10 M /l, <10 ppm respectively. (Smith D, 2007)
(Phillips M, 2000) (Hamilton LH, 1998).

Most of them are end product of lipid, nitrogen, cholesterol, alcohol, carbohydrate,
protein or aminoacid metabolism, oxidation of proteins, pancreatic insufficiency,
carbohydrate malabsorption intolerance, abnormal gut flora, bacterial gut overload, liver
or renal failure, or subclinic trimethylaminuria disease.

A list of exhaled volatiles in patients with systemic disease, such as diabetes mellitus,
sleep apnea, H. pylori infection, sickle cell disease, asthma, breast cancer, lung
carcinoma, chronic obstructive pulmonary disease, cystic fibrosis, liver disease, cirrhosis,
uremia, kidney failures, trimethylaminuria, has been published (Whittle CL, 2007).

Distinction between Oral and Breath Halitosis : Both give similar sign of bad
odor in the mouth and/or breath.
Where is odorous gas emitted from ?
The mouth or from the breath?
The difference is important for both, diagnosis or treatment. 

This handout lists useful tools to distinguish between them, including the three points noted in the MEBO Blog post, "The MEBO Conference and Social Meetup in Memphis," scroll down to section, "HALITOSIS FROM MOUTH OR BREATH."

See handout for additional information.


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