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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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BO Sufferers Podcasts

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

https://www.meboblog.com/2023/01/denver-tmau-test-survey-tbc-who-it-is.html

Friday, October 24, 2014

New paper associates colorectal cancer with trimethylamine-oxide

Paper : TMAO and colorectal cancer
A new research paper by researchers at Cornell University have hypothesized that trimethylame-n-oxide (TMAO) may be associated with colorectal cancer. This would be the 2nd major disease to be hypothesized to be associated with higher TMAO levels. The other is heart disease, first postulated in 2012 by Dr Stanley Hazen et al at Cleveland Clinic.

Paper :  
Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study : Link
Cornell University

How might this help trimethylaminuria ?  
For people who feel they have a metabolic malodor problem caused solely by trimethylamine, now that TMAO has been associated with 2 major diseases in humans, it is likely that much research will now take place regarding trimethylamine in humans, and possibly how to prevent or neutralise it. So TMAU patients are likely to be a big benefactor of this research.

TMAO and TMA
Trimethylamine-n-oxide (TMAO) is oxidized trimethylamine (TMA). Trimethylamine in humans is thought to be generated solely from any TMA or TMAO ingested (e.g. fish), or by gut flora altering TMA precursors in the diet (such as choline and carnitine). In healthy humans the TMA is oxidized by FMO3 enzyme into TMAO and then excreted. You would think that TMAU people would not have high TMAO levels (and so less likely to be exposed to a hypothesized Heart Disease or cancer risk), but in many cases it seems TMAU people have both high TMA and TMAO levels. Keep in mind the connection to these 2 major diseases is not the consensus (yet).       

FMO3
While they are likely to be looking at ways of reducing/blocking TMA, at the moment we do not know if they will take an interest in FMO3 enzyme and it's proper functioning as well. Currently FMO3 is a 'mixed function oxidase' enzyme generally regarded as a 'negligible' player in the grand scheme of enzymes in the body, although this is likely an underestimation. However, if they stop/reduce/neutralise TMA then they may not feel it necessary to look at ways to make FMO3 function properly. Only time will tell.

However, it is hoped that now there will be plenty of research around the world at how to lower TMA in humans. 

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