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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
click to read more

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Sunday, December 20, 2015

DMB reduces trimethylamine gut formation

From press release 
Now, the team has identified a naturally occurring inhibitor called DMB – 3,3-dimethyl-1-butanol, found in some cold-pressed extra virgin olive oils and grape seed oils – that reduced levels of TMAO and reduced atherosclerosis in mice
New TMAO paper by Dr Hazen et al at Cleveland Clinic
Their 2011 paper suggested TMA-oxide may be main cause of CVD
Since then looking for therapies
Main aim seems to have been to stop TMA formation in gut
Looks like they have been trying various candidates to stop TMA formation
This paper suggests 3,3-dimethyl-1-butanol  (DMB) inhibits TMA formation in gut
DMB is a natural compound found in certain foods and drinks
Perhaps DMB will be the compound in the OTC product they plan to sell via Proctor & Gamble
If you think TMA is the sole reason for your malodor, this could be a future therapy for 'TMAU'

TMA inhibited by DMB research : link to full paper
Cleveland Clinic official press release : link
UK Daily Mail article : link
Prof Colin Dolphin comment : link  

In 2011 Dr Stan Hazen et al at the Cleveland Clinic first put forward the hypothesis that TMA-oxide may be a strong (perhaps strongest) biomarker for CVD. Since then it seems they have been looking at ways to deal with this. It seems their main aim was to stop trimethylamine formation in the gut. It looks like they have been looking at many compounds that may do this, and have now published of finding a compound, 3,3-dimethyl-1-butanol (DMB), which naturally occurs in some foods and drinks, which seems to inhibit TMA formation in the gut (e.g blocks/interferes with the choline to TMA process created by enzymes in gut bacteria).

It is not clear if this discovery is at an advanced stage or if they have just proved the concept and that DMB may not even be the ideal compound. We do know they signed an agreement with Proctor and Gamble in August to produce an #over the counter' product in the future that will help with 'TMAO management'.

So at the moment we know little other than they have proved the concept of blocking/reducing TMA formation in the gut, but will have to wait to see what happens next. Obviouisly if it blocks TMA formation then it should be a therapy for TMAU too (if you feel that TMA is the sole compound causing your malodor). With the therapy meant for Heart disease and perhaps other seriouos metabolic disorders, we can assume a lot of money has gone into this research and probably will in the future.

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Anonymous said...

Thank you for posting, this is very interesting. Hopefully it can benefit us in the near future

Dec 24, 2015, 7:51:00 AM
kelly carroll said...

I don't know which parent I inherited this condition from. I do know that my dad died from cvd at 75. This cold be the reason. I wish I was a scientist so that I could help find a cure. Every time I buy a lottery ticket I think to myself...please God let me win so I can donate to rare disease issues. FIRSTLY a cure for us tmau sufferers. Secondly everything else. That is all I ask.

Jan 18, 2016, 10:42:00 PM
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