Admin Control Panel

New Post | Settings | Change Layout | Edit HTML | Edit posts | Sign Out


March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country

MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

Popular Posts (last 30 days)

Upcoming get-togethers

Let us know if you want a meetup listed
Follow MeBOResearch on Twitter

Blog Archive

Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Sunday, December 4, 2016

References on TMAU in English and Spanish

Just Yesterday a sufferer in Mexico said she has to do a thesis for her Master's in Science degree, and wants to do it on TMAU. She asked me for information. I really believe that MEBO should support sufferers who are students, especially when they want to focus their studies on the medical causes and treatment of breath and body odor conditions. So, I spent most of the day researching college level info and giving her experts' information so that she may contact them, if she wants.

I think I'll share the info with this group as well. The first part is in Spanish, since she is doing her thesis in Spanish, and the 2nd part is in English.


Organización de apopyo en América Latina y España

Entrevistas con expertos:

Webinar sobre la TMAU por la Dra. Mercedes Serrano

Resumen de la Trimetilaminuria y su protocolo

Guia Metabólica

Trimetilaminuria congénita, adquirida y transitoria

Diagnóstico de trimetilaminuria en Madrid y Barcelona

Artículo Federación Española de Enfermedades Raras (FEDER) (Si recuerdo bien, el artículo dice equivocadamente que se puede comer la yema de huevo pero no la clara, y es lo opuesto. La yema es muy alta en colina.)

Pros y Contras de la prueba de TMAU

Resumen del protocolo de reduccion de Olor por TMAU

Sobre la Trimetilaminuria Primaria y Secundaria

Consecuencias Psicosociales del olor corporal incontrolable

Supresión de la producción intestinal como tratamiento para la TMAU






Utility gene card on Trimethylaminuria

FMO3 coding sequence

TMAU paper by New Zealand test lab

Carnatine, not just choline to be avoided in TMAU diet



Links to discussion of liver damage due to decrease of choline in the diet.

Links to discussion of the effects of DMB on choline,  l-carnitine, and lecithin ingestion –> TMA production by gut bacteria –> TMAO production by FMO3 metabolic enzyme in the liver.

These articles to be saying is that experts' research indicates that taking DMB, especially with a low choline diet, decreases TMA levels and increases choline levels in the body, and thus may not cause nonalcoholic fatty liver disease. Instead of decreasing the amount of choline that goes to the liver, it helps protect the choline from the gut bacteria would have normally consumed to produce odorous TMA. DMB actually prevents the bacteria from consuming choline, so the choline goes to the bloodstream to the liver. DMB also prevents the bacteria from producing TMA. It's a win-win situation, but only for sufferers who do have TMA producing bacteria in the gut.

For sufferers who don't have TMA producing bacteria in the gut, DMB won't really have much effect. These sufferers really need for the MEBO Metabolomic Profiling research project to give more answers on other causes of odor conditions. However, a very strict low choline diet is definitely a danger to TMAU sufferers and non-TMAU sufferers for developing nonalcoholic fatty liver. We do need to keep in mind that there may also be other causes of nonalcoholic fatty liver, such as medication and diet.

That’s exactly what its implying, especially vital for TMAU sufferers with bacterial overgrowth problems, the vast majority of the choline being converted to TMA not leaving much at all by the time it gets to your liver leaving very little choline to decongest the fat in our livers, along with our reduced choline intake its quite worrying what impacts this has on our livers.

That along with the mental health benefits from choline which I’ve always been worried about, too many TMAU sufferers are subjected to mental health problems because of the nature of the illness, the reduced choline levels very much amplify this. See here:

Treating Depression and Anxiety Through Choline Supplements

Information on Choline, as an essential nutrient.

Sufferers of TMAU need to go on a low choline diet in order to control their odor symptoms. However, it can be very dangerous to one's health because choline is an essential nutrietn. Low choline diet can cause non-alcoholic fatty liver and increased anxiety and depression. It causes severe neurological abnormal development in fetuses.


María de la Torre
Founder and Executive Director

A Public Charity
MEBO's Blog (English)
El Blog de MEBO (español)

MEBO Brasil - Blog (Portuguese)

SUPPORT THE MEBO MISSION: Click Amazon button at right sidebar of this blog when shopping online for the holidays
at no extra cost to you.
MEBO gets small commission from Amazon.

Please use your credit card to make your donation to MEBO.

Subscribe for latest posts : Enter your email address:

Delivered by FeedBurner

A EURORDIS and NORD Member Organization


Post a Comment