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MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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or contact
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Videos : TMAU stories

Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
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NORD Member Organization
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RESEARCH DETAILS

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$ 568.00/USD

TOTAL at today's ROE
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£1,398.07 = $1,745.14

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Tuesday, March 20, 2018

Sheffield CH publish a TMAU document

Sheffield Children's Hospital have published a TMAU document on their website.
It's an ABRIDGED version of the powerpoint they presented to the UCL London TMAU community group.
While the document is welcome it's still a long way from what a lone national test lab could offer the public.
The lecture was to explain the differences between the 'old' TMAU test they did up to 2016, and the 'new' method.

Sheffield CH TMAU Powerpoint PDF
Page with document link

Some initial eye-catching about the document.

 Assay running for one year
 n = 725
 Includes repeat samples and monitoring patients,
including those on treatment
 147 results below limit of quantitation
 Very low levels, unable to provide quantitative result
 453 results within ref range for TMA and N-oxidation
 94 results outside ref ranges for TMA and N-oxidation
 8 results outside ref range for TMA, within ref range
for N-oxidation
 23 results within ref range for TMA, outside ref range
for N-oxidation
 Mainly known patients on dietary restriction

The document includes a graph of the 725 results



They say :

 Important to note:
 Results from the ‘old’ method cannot be directly
compared to those using our ‘new’ method
 Results obtained by our method cannot be
interpreted using other laboratories reference ranges
(such as those quoted on scientific papers)

Whether that is subjective cannot be confirmed.

Sample Exchange Program between the 4 main known  TMAU labs :
The 4 best known TMAU test labs seem to test each others samples in a small survey each year, presumably to double check results.
It's not clear what this entails. Probably retesting samples to see if they get same results, even though they all use different methods. 
Perhaps they could add South Africa to their program.

Ref ranges :
These seem to have been taken from a 1997 paper (Maschke et al) and from 37 'control' samples to confirm.
1997 paper
Whether this ref range is conservative or 37 controls is standard is unknown.

So the document is welcome but still more for the public would be welcome.
Such as a TMAU page on the site where the public can get details how to test etc. 
People might think that a good minimum for a national test lab. 

Comments are welcome.

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A EURORDIS and NORD Member Organization

3 comments:

Deb said...

Hi, do you recommend doing the test at Sheffield? or is it better to wait? Thanks

Mar 21, 2018, 9:32:00 AM
blogcontributor2 said...

well it looks like around 16% got a tmau diagnosis.
I think the old test was more.
I expect most people to be 'normal' though.
So you pays your money ...

Mar 21, 2018, 10:17:00 AM
blogcontributor2 said...

with the old test about 1/3 got a positive

Mar 21, 2018, 11:11:00 AM
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