As usual, Danny Kunz most graciously provided the MEBO community with a very informative PowerPoint presentation on the Causes of Body Odor. This PowerPoint was to be presented and discussed at length at the MEBO Annual Conference, Savannah, Georgia 2018. Since we did have some technical difficulties and we were unable to hear the video, I am now presenting it here.
Discussion below on some points of interest that Danny tells us:
Histamine in the gut is bad because it has a strong impact on tight junction regulation of intestinal cells. In fact, "fecal body odor seems to be related to histamine degradation deficiency" The significance of gut wall health (tight junction regulation of intestinal cells) was discussed in the conference. Sufferers are recommended to consult with their physician if they experience prolonged allergic reactions, especially of the bowels, such as food sensitivities and/or indigestion, etc.
It is important to maintain good health of the digestive tract in the fight against odor conditions and PATM. Sufferers are recommended to consult with their gastroenterologist when experiencing any intestinal discomfort, including but not limited to, bloating, constipation, diarrhea, abdominal tenderness, painful bowel movement, hemorrhoids, rectal bleeding, etc.
It looks like histamine concentrations are highly important for the tight junction regulation of intestinal cells.
The tight junctions are important for the direct paracellular transport of electrolytes into the blood without transition through the intestinal cell metabolism.
Increased open tight junctions [leaky gut] will further lead to an increased surface area of the intestinal cells [IBS] and are as a result, a strong regulator of passing amines and their level of being processed.
http://bodyodorresearch.blogspot.com/2017/05/histamine-has-strong-impact-on-tight.html
Clinical significance of the opening of intercellular tight junctions (increased intestinal permeability), any of which may result in opening of tight junction, resulting in the passing of electrolytes into the blood without transition through the intestinal cell metabolism.
Clinical significance [Wikipedia]
- Transcellular route (pathway): The route through cells, as opposed to between the cells.
- Paracellular route: the route between cells
- Tight junction: A type of cell junction formed between epithelial cells of vertebrates wherein the outer layers of two adjacent cells fuse, thereby serving as a barrier to the passage of fluid between cells
An informative site on Crohn's Disease: Verywell.com, a health & wellness site that provides simple, expert advice to 20M readers a month, https://www.verywellhealth.com/crohns-disease-4013910
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