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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Tuesday, April 24, 2018

Danny Kunz on Fecal body odor smell type

Danny Kunz and the Citizen Research Group he is a member of, created a blog, BODY ODOR RESEARCH BLOG, in which they talk about different types of body odor, i.e., fish, fecal, sweaty body odor, and TMAU, Bromhidrosis, Candida pathogenesis in Bromhidrosis, IBS, tight junction, and many other topics.

In the MEBO Annual Conference, Savannah 2018, we discussed some of these topics, including the extensive Food diet lists for fecal body odor and Bromhidrosis patients.

The fecal body odor smell type

April 12, 2017

So for people being TMAU negative and having a fecal body odor type it is very likely to have an enzyme defect in the histidine degradation pathway over the HNMT enzyme.
As stated in an earlier post, the most prominent reported smell type for TMAU2 patients was the fecal smell type. But not only TMAU positive patients reported such a type of smell, another body odor sufferer type do show the same fecal body odor pattern. Interestingly nearly all of those non TMAU patients report having Irritable Bowel Syndrome (IBS) as well. We took a closer look into the combined bacterial and human metabolism. The central chemical compound involved in the fecal smell seems to be indole.

Indole is produced within the bacterial metabolism as a precursor of tryptophan. As major source the bacteria use glycolysis based on sugar, carbohydrates, ...

To let the bacteria produce too much indole we found certain criteria:
- Tryptophan absorption of the intestinal cells is lower than the serine and glycine absorption
- Histidine malabsorption is present
- Tyrosine malabsorption is present

Why do TMAU2 patients now show a fecal smell, don't they have a choline and betaine malabsorption?

Yes, they have, but it seems that there are several different enzyme defects in the choline degradation pathway leading to such a choline malabsorption.

Some of those defects do also have an indirect impact on the histidine degradation over the histamine n-methyltransferase (HNMT) enzyme, which leads to a histidine malabsorption also.

Additionally the tryptophan and tyrosine degradation is further cuppled to the histidine degradation and as a result they show a tryptophan and tyrosine malabsorption also.

So for people being TMAU negative and having a fecal body odor type it is very likely to have an enzyme defect in the histidine degradation pathway over the HNMT enzyme.

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