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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Tuesday, April 24, 2018

Danny Kunz on Fecal body odor smell type

Danny Kunz and the Citizen Research Group he is a member of, created a blog, BODY ODOR RESEARCH BLOG, in which they talk about different types of body odor, i.e., fish, fecal, sweaty body odor, and TMAU, Bromhidrosis, Candida pathogenesis in Bromhidrosis, IBS, tight junction, and many other topics.

In the MEBO Annual Conference, Savannah 2018, we discussed some of these topics, including the extensive Food diet lists for fecal body odor and Bromhidrosis patients.


The fecal body odor smell type

April 12, 2017

So for people being TMAU negative and having a fecal body odor type it is very likely to have an enzyme defect in the histidine degradation pathway over the HNMT enzyme.
As stated in an earlier post, the most prominent reported smell type for TMAU2 patients was the fecal smell type. But not only TMAU positive patients reported such a type of smell, another body odor sufferer type do show the same fecal body odor pattern. Interestingly nearly all of those non TMAU patients report having Irritable Bowel Syndrome (IBS) as well. We took a closer look into the combined bacterial and human metabolism. The central chemical compound involved in the fecal smell seems to be indole.

Indole is produced within the bacterial metabolism as a precursor of tryptophan. As major source the bacteria use glycolysis based on sugar, carbohydrates, ...


To let the bacteria produce too much indole we found certain criteria:
- Tryptophan absorption of the intestinal cells is lower than the serine and glycine absorption
- Histidine malabsorption is present
- Tyrosine malabsorption is present

Why do TMAU2 patients now show a fecal smell, don't they have a choline and betaine malabsorption?

Yes, they have, but it seems that there are several different enzyme defects in the choline degradation pathway leading to such a choline malabsorption.

Some of those defects do also have an indirect impact on the histidine degradation over the histamine n-methyltransferase (HNMT) enzyme, which leads to a histidine malabsorption also.

Additionally the tryptophan and tyrosine degradation is further cuppled to the histidine degradation and as a result they show a tryptophan and tyrosine malabsorption also.

So for people being TMAU negative and having a fecal body odor type it is very likely to have an enzyme defect in the histidine degradation pathway over the HNMT enzyme.



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