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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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UK residents survey : Prof Shephard/MEBO (until 31/1/21) click to visit survey
click to Read more/less

Prof Elizabeth Shephard is conducting a TMAU fact-finding survey for UK RESIDENTS. She plans to use it to raise awareness with decision-makers, such as perhaps MPs. It closes 31 Jan 21.

who is the survey intended for ?
UK residents who identify with TMAU

Living with TMAU study

We invite you to participate in a research project entitled ‘Living with TMAU’.

click to visit survey

survey full url :

Participation in the project will involve completion of a short questionnaire, which aims to capture the experiences of those living with the condition. There are two questionnaires.

For individuals with TMAU over the age of 18

For a parent or guardian of a child with TMAU.

The results from the questionnaires will be compiled to produce a report that will be available for you to use, for example, to lobby your MP. The findings will be used to reach out to policy makers in the UK to have TMAU recognised as an invisible disability and to make people aware of what it is like to live with the disorder. The report will be made available on the MEBO, UK website.

To complete either questionnaire you must be over 18 and resident in the UK. The questionnaire responses are anonymous and no personal identifiers will be collected.

The questionnaire closes 11:59 pm (GMT) Sunday 31st January 2021.

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Sunday, August 12, 2018

Dr. Hazen's Anti-TMA pill works in mice

CLEVELAND CLINIC work on a 'TMA-inhibitor' pill continues.
New paper released on Aug 6 2018.
Pill worked on MICE.

Regular readers will know that CLEVELAND CLINIC HEARTLAB published a theory in 2011 that TRIMETHYLAMINE-OXIDE is a main factor in causing CARDIOVASCULAR disease.

An obvious therapy would be to block TRIMETHYLAMINE production in the gut.
The biggest source of TMA in most humans is likely to be from degradation of Choline and Carnitine in the gut by gut microbes.

Cleveland Heartlab looked for a way to stop gut microbes creating TMA, and have been working on this since 2011.

Cleveland published a new paper on August 6 2018.
New paper says they have now have compounds that fit into a pill that will INHIBIT TMA formation in the gut from Choline/Carnitine by gut microbes ... and the news is it works on MICE.
Human trials will follow.

 ... now have something that fits in the size of a pill and will completely suppress TMA production.
The compounds in this manuscript work 10,000 fold more potent than DMB
Newsroom, Cleveland Clinic

The pill has a number of compounds similar to TMA in structure (analogues).
The gut microbes absorb these compounds rather than TMA.
In effect 'tricks' the TMA enzymes of the microbe, and fills up that quota ?
Microbes normally 'cleave' the TMA from choline/carnitine, via cutC enzymes (?)
The bacteria are not killed, it just interferes with the microbes enzymes that cleave TMA from choline.

The pill will be an 'OVER THE COUNTER' supplement.
No prescription necessary.
The date of marketing is unknown. Could be 2020 or further.
There seems to be a patent for the pill taken out circa 2017. It looks to be a combo of DMB and other natural compounds that are similar in structure (analogues) to choline/carnitine.

If there is no TMA in the gut, there is no TMA to absorb in the blood.
So in effect, it may be a 100% therapy for TMAU.
It will not improve FMO3 function.
Kind of like an alcoholic with no alcohol. As long as they have no alcohol they are 'cured'. 
Presumably it has no effect on TMA sourced from FISH in the diet. So fish would still be off the menu.

For those who feel TMA IS THE ONLY SOURCE of their malodor, it would be in effect a wonderful therapy.

A hope is that the pill is on sale on 2020, but this is a guess and it may be a few years more than that.

The pill is for the Heart Disease / Stroke market, so it will definitely be made. 

Cleveland Clinic used to supply MEBO with a TMAU urine test from 2011 - 2017, but it sadly had to end.

Links :
Abstract of paper : TMA-INHIBITOR IN MICE

Patent for the anti-TMA pill ? : link

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