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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Tuesday, September 1, 2020

Fluxovas pills to inhibit TMA ? 1st post

A rareconnect reader has spotted that a 'drug' intended to block Trimethylamine formation in the gut is on sale in Italy.
It has been difficult to get info so far.
This is a first post on the subject.

drug name : FLUXOVAS
manufactured : ITALY ? 
researchers : ITALY LAB ?
drug based on  : RESVERATROL and CATECHINS ?
active ingredient name : TAURISOLO ? (based on above, patented ?)

Example of online seller : : Fluxovas 

The researchers behind Fluxovas seems to be Italy-based (Naples ?)
In a 2019 paper the details are :

Giuseppe Annunziata, Maria Maisto, Connie Schisano, Roberto Ciampaglia, Viviana Narciso, Gian Carlo Tenore, and Ettore Novellino

Department of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano 49, 80131 Naples, Italy

2019 Paper
Effects of Grape Pomace Polyphenolic Extract (Taurisolo®) in Reducing TMAO Serum Levels in Humans: Preliminary Results from a Randomized, Placebo-Controlled, Cross-Over Study
Link to Full Paper (includes researcher email addresses)

Trimethylamine N-oxide (TMAO) is considered a novel risk factor for cardiovascular diseases. Several studies demonstrated that polyphenols are able to inhibit the growth of TMA-producing bacterial strains, and resveratrol (RSV) reduced TMAO levels in mice. In the present study, we evaluated the TMAO-reducing effect of a novel nutraceutical formulation containing grape pomace extract in humans (Taurisolo®). The Taurisolo® polyphenol content was evaluated by a High Performance Liquid Chromatography-diode-array detector (HPLC-DAD) method, and RSV was monitored as an indicative marker. After in vitro GI digestion, intestinal bioaccessibility of RSV was 92.3%. A randomized, placebo-controlled, cross-over trial was carried out to evaluate the TMAO-reducing effect of Taurisolo®. In acute, the maximum levels of RSV were detected both in serum and whole blood 60 min after the administration of Taurisolo®; in chronic, a significant increase of RSV was detected in serum after the 4-week treatment. After 4 weeks, the levels of TMAO were significantly decreased in the treatment group compared to placebo (63.6% vs. 0.54%, respectively, P < 0.0001). In conclusion, our data show that Taurisolo® may represent a novel and useful natural remedy to reduce prognostic markers for incident cardiovascular events. Undoubtedly, further in vitro and in vivo studies need to be performed in order to elucidate possible mechanisms of action and corroborate our preliminary results.


Another article which mentions TAURISOLO : RSC Article

Any more info on this is welcome (e.g. USA Sellers etc).

update :
more info has been received :
It's classed as a 'food supplement', so is not a drug and is available prescription-free.
It seems new channels to buy it (or an announcement) may be available in the next few days.  

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Anonymous said...

Hi is this true? I dknt want false hope
Can they deliver in canada

Sep 2, 2020, 1:06:00 PM
Anonymous said...

Is this any different from resveratrol? I would think. that Mega-Resveratrol would be the same thing and it is available in the United States for less money.

Sep 6, 2020, 2:27:00 PM
Anonymous said...

Re the second comment: resveratrol is a part of the grape. Fluxovas is grape pomace, which is the rest of grape. This is the same as grapeseed extract in the United States as far as I can tell. The Synergy Company has pure grapeseed extract for sale for $31.00. This company makes the highest quality products.

There are statements that grape seed pomace works against Covid-19. Probably a combination of resveratrol and grapeseed extract, two different supplements but taken together, would be of value in
increasing immunity to Covid-19.

You can easily do your own research on Google. It only takes a few minutes to search out Fluxovas, Taurisol,
grape pomace, and the rest. The Synergy Company also has resveratrol.

Sep 6, 2020, 8:05:00 PM
Unknown said...

I got fluxovas from an Italian friend because can t find it in France and in a week time the result is beyond expectation for having tried everything from metronazidole to Lglutamine , riboflavin etc etc etc etc . ...So I took two pills a day one morning one bedtime and then switched after first sign of improvement (4 or 5 days later) to one take a day and I keep on drinking liquid chlorophyll so the result : Skin no smell mouth much lighter no longer this taste, mind : a good feeling , still a little in breath (I can tell with the mask) but nothing compared to what it was before ... just poo smells stronger so I guess it s just adjustment of the gut Among the benefits I noticed : lighter legs and an overall much better feeling, less tired So I m starting week number two tomorrow I read that it takes two weeks for the choline level to go down so I m still full of hope but for now if it keeps on like this it s a real improvement

Sep 25, 2020, 5:13:00 PM
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