A new paper presents a new Trimethylamine-inhibitor.
They call 'compound 5' ?
Seems to be based on a Histadine Compound ?
authors :
The 'physical' work in the paper seems to be done by a Stanford Academic of chemical structure ?
The' theory' by an Academic researcher based in a Spanish Uni.
Full paper is pay access
Moustafa Gabr 1, Katarzyna Świderek 2
Affiliations
1 Stanford University, Radiology, 300 Pasteur Drive, 94305, stanford, UNITED STATES.
2 Universitat Jaume I, Department de Quimica Fisica i Analitica, SPAIN.
Abstract
Affiliations
1 Stanford University, Radiology, 300 Pasteur Drive, 94305, stanford, UNITED STATES.
2 Universitat Jaume I, Department de Quimica Fisica i Analitica, SPAIN.
Abstract
Uneducated skim-read thoughts on the paper
TMA-inhibitors would probably have been around decades ago if anyone looked. They look for choline analogs ? Probably simple too.
No-one looked until around 2011 (still waiting for product to reach market).
This seems to be the 3rd known TMA-inhibitor research ? (others ... Hazen-P&G, Balskus lab?)
Balskus lab don't seem to be bringing a product to market ?
On this paper :
This paper has a good vibe as it seems simple process. A theorist and a practitionist.
Probably took pretty quick to do.
Also looks like 1 compound.
It's unknown if that is their research over or if they will continue and maybe create a product.
The reason for the paper will be all the talk about TMAO possibly being inplicated in CVD and kidney disease etc.
![[Facebook Share]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sZutahdjjxUS5adhzzaPFTZbhKd55SYm-RFrmBXfbRZsIlQ8dqBjqVYoeWLC3OLRI1sGr5bKoEJm7uMfFG9SLd0wPd0A4=s0-d){kind=small}
UK 
Spain 
6 comments:
Hmmm....I know some people at Stanford. Maybe we could create a little awareness in this department.
We still waiting for proctor and gamble to bring their product to market, they lied about the time it will come, so at this point, I will find my own cure, or what works for me, they been messing around with this for years, and still nothing....go digure
What would happen if one took a small tablet of histidine supplement just before eating a high -choline food?
Would there be any effect, or is the chemical process more complicated?
There are several histidine supplements on the market. I wish a doctor already familiar with TMAU problems could advise us on how to use this information with products already available, so we wouldn't have to hope the researchers might develop a new product especially for TMAU.
to the person who said you know people at Stanford. I agree create a little awareness if you can. What department can we talk with?
If you look up Moustafa Gabr on Google, you find that he is connected with the Radiology Department at Stanford. I don't know how one goes about this properly. Perhaps an organization like NORD, or a representative of MEBO could write a letter just to let them know that the problem of TMAU exists and that we are following this line of research with great interest, etc.
It would seem that there wouldn't even be a need for a new product if we only knew how to take available histidine supplements (of which there are many) in such a way as to affect TMAU. Who could we ask?
Looking up "histidine compound 5" on Google, I find that it is a compound that includes iodine and nitrogen, in addition to histamine.
At least I think that's what it means!
So...what if one took a little histidine tablet, a little iodine (kelp) and a little nitrogen, all together? Would this be roughly equivalent to Compound 5?
Over the years, cysteine, iodine and nitric oxide have been mentioned as helping with TMAU. L-arginine and l-ornithine are very effective. Dr. Weil has a supplement that increases blood flow with the use of nitric oxide. So, this is the general area. Now, we just need something specific to try.