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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Sunday, June 8, 2008

Phenylketonuria and Maple Syrup Urine disease. Recognised bloodborne odor problems

Main points :
From Merck manual
Other accepted bloodborne odors caused by errors in metabolizing certain amino acids
The main point : Can people with only mildly defective genes (or combos with 1 very bad copy, a null allelle) who are regarded 'asymptomatic' have a 'secret' transient odor problem ?

Phenylketonuria : mousy odor
Maple Syrup Urine Disease : sweet smell

Both Phenylketonuria and Maple Syrup Urine disease in their purest forms (and variations close to that) are serious life-threatening health problems that will be quickly diagnosed (that's how the medical system mostly discover health problems). But what about 'normal' 'carriers' or having one 'serious' copy and a combo with a mild defective copy and other variations ? Perhaps these people are 'asymptomatic' to their doctors, but they silently suffer from transient odor issues that they can't smell and doesn't affect their physical health.

Quotes from Merck manual :

"Untreated children often give off a "mousy" body and urine odor as a result of a by-product of phenylalanine (phenylacetic acid) in their urine and sweat."

Maple Syrup Urine Disease
" and the odor of maple syrup particularly during physical stress, such as infection or surgery."


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