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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Thursday, August 28, 2008


One of the most obvious way of medically detecting why someone has bloodborne odors would seem to be by testing for smelly metabolites in their body secretions. Probably urine would be the easiest method, although the Monell Institute used this method recently to test for airborne metabolites emanating from skin. An example of this being used to detect smelly metabolites is the trimethylamine urine test, where they test for one smelly metabolite only. For a problem such as fecal body odor, it would seem to make sense to not rule out any smelly volatile organic metabolite until at least the 'problem' was medically defined. The technology to test for these types of metabolites seems to be already fairly widespread in metabolism laboratories across the world (gas chromograph-mass spectrometry and other such testing equipment).

In it's most extreme form, the testing of metabolites is a science in itself, known as Metabolomics. Currently The Human Metabolome Project is trying to discover all possible metabolites in humans, but have a way to go. However, most 'smelly' human metabolites may already be known.

Unlike the situation in genomics, where the human genome is now fully sequenced and freely accessible, metabolomics is not nearly as developed. There are approximately 2900 endogenous or common metabolites that are detectable in the human body. Not all of these metabolites can be found in any given tissue or biofluid. This is because different tissues/biofluids serve different functions or have different metabolic roles. To date, the HMP has identified and quantified (i.e. determined the normal concentration ranges for) 309 metabolites in CSF, 1122 metabolites in serum, 458 metabolites in urine and approximately 300 metabolites in other tissues and biofluids.
An example of a metabolics research center is the Nutrition Research Institute of the University of North Carolina at Chapel Hill. They have a core facility that will perform two different types of metabolomic analysis: metabolic fingerprinting and metabolic profiling.
We can then begin to develop concepts of the mechanisms involved in the observed changes. At this time, we know the identity of 300-500 molecules in blood (of more than 2000), and there is a great deal of work to be done to identify and to be able to accurately measure the entire metabolome. Some of these molecules do not come from human metabolism, but from the metabolism of bacteria in our intestines. In our bodies there are more bacterial cells than there are human cells. Metabolomics is a new tool for studying what it is that these bacteria do with the food that we eat.
What is Metabolomics?

Metabolomics is defined in the MSN Encarta World English Dictionary [ North American Edition] as the, "study of cell metabolism: the measurement of the metabolites of low molecular weight in an organism's cells at a specific time under specific environmental conditions."

Wikipedia describes it as the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind" - specifically, the study of their small-molecule metabolite profiles. (Daviss)

Perhaps someday if there is ever any research interest in bloodborne body odor and halitosis, it's likely that this kind of testing will play a major role, at least in detection.


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