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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Friday, August 29, 2008

Xenobiotic metabolism enzymes : an attempt at an explanation

This is an attempt to explain what are often refered to as the 'xenobiotic enzymes' or 'drug metabolizing enzymes' (amongst other hard to define names) . These are the cell enzymes that often mostly deal with 'external' chemicals that get into the bloodstream (especially drugs). Usually they are most abundant in the liver (hepatic enzymes) but they can be present anywhere.

They are often classed as phase1/phase2 (biotransformation) enzymes.

Phase1 is the oxidizing layer (the 'non-synthetic reaction' enzymes) (they also do other things, such as reduction)
the main family of phase1 (the heavy duty ones) are the CYP450 family. The FMO family are another phase1 enzyme.

The phase2 enzymes are the 'conjugation reaction enzymes'. They add something to the chemical to completely neutralize it. for instance a sulfur molecule. The main phase2 enzyme reactions are glucuronidation, sulfation, methylation and glutathione, acetylation, and amino acid conjugation. Both phases aren't always needed to detoxify something. For instance trimethylamine only needs to be oxidized by FMO3.

Most of these enzymes DNA can be increasingly switched on or off by chemicals. This is known as induction or inhibition. For instance a compound in grapefruit juice can inhibit many of the CYP450 enzymes. FMO is probably still taught as being uninducible/uninhibitable, but a study has shown a compound in cruciferous vegetables can inhibit FMO.

Everyones 'maximum' amount of of each enzyme varies in general. Since these enzymes often activate or detoxify drugs, they can often explain why someone reacts badly to certain medicines. Researchers are trying to understand these reactions through the science of pharmacogenetics

These enzymes also alter a lot of other chemicals in the body. for instance, detoxifying/activating hormones, neurotransmitters etc ('endogenous substrates').

drug metabolizing enzymes


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