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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Friday, August 29, 2008

Xenobiotic metabolism enzymes : an attempt at an explanation

This is an attempt to explain what are often refered to as the 'xenobiotic enzymes' or 'drug metabolizing enzymes' (amongst other hard to define names) . These are the cell enzymes that often mostly deal with 'external' chemicals that get into the bloodstream (especially drugs). Usually they are most abundant in the liver (hepatic enzymes) but they can be present anywhere.

They are often classed as phase1/phase2 (biotransformation) enzymes.

Phase1 is the oxidizing layer (the 'non-synthetic reaction' enzymes) (they also do other things, such as reduction)
the main family of phase1 (the heavy duty ones) are the CYP450 family. The FMO family are another phase1 enzyme.

The phase2 enzymes are the 'conjugation reaction enzymes'. They add something to the chemical to completely neutralize it. for instance a sulfur molecule. The main phase2 enzyme reactions are glucuronidation, sulfation, methylation and glutathione, acetylation, and amino acid conjugation. Both phases aren't always needed to detoxify something. For instance trimethylamine only needs to be oxidized by FMO3.

Most of these enzymes DNA can be increasingly switched on or off by chemicals. This is known as induction or inhibition. For instance a compound in grapefruit juice can inhibit many of the CYP450 enzymes. FMO is probably still taught as being uninducible/uninhibitable, but a study has shown a compound in cruciferous vegetables can inhibit FMO.

Everyones 'maximum' amount of of each enzyme varies in general. Since these enzymes often activate or detoxify drugs, they can often explain why someone reacts badly to certain medicines. Researchers are trying to understand these reactions through the science of pharmacogenetics

These enzymes also alter a lot of other chemicals in the body. for instance, detoxifying/activating hormones, neurotransmitters etc ('endogenous substrates').

keywords:
induction
substrate
inhibition
CYP450
phase1/phase2
drug metabolizing enzymes
endogenous/exogonous


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