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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, August 29, 2008

Xenobiotic metabolism enzymes : an attempt at an explanation

This is an attempt to explain what are often refered to as the 'xenobiotic enzymes' or 'drug metabolizing enzymes' (amongst other hard to define names) . These are the cell enzymes that often mostly deal with 'external' chemicals that get into the bloodstream (especially drugs). Usually they are most abundant in the liver (hepatic enzymes) but they can be present anywhere.

They are often classed as phase1/phase2 (biotransformation) enzymes.

Phase1 is the oxidizing layer (the 'non-synthetic reaction' enzymes) (they also do other things, such as reduction)
the main family of phase1 (the heavy duty ones) are the CYP450 family. The FMO family are another phase1 enzyme.

The phase2 enzymes are the 'conjugation reaction enzymes'. They add something to the chemical to completely neutralize it. for instance a sulfur molecule. The main phase2 enzyme reactions are glucuronidation, sulfation, methylation and glutathione, acetylation, and amino acid conjugation. Both phases aren't always needed to detoxify something. For instance trimethylamine only needs to be oxidized by FMO3.

Most of these enzymes DNA can be increasingly switched on or off by chemicals. This is known as induction or inhibition. For instance a compound in grapefruit juice can inhibit many of the CYP450 enzymes. FMO is probably still taught as being uninducible/uninhibitable, but a study has shown a compound in cruciferous vegetables can inhibit FMO.

Everyones 'maximum' amount of of each enzyme varies in general. Since these enzymes often activate or detoxify drugs, they can often explain why someone reacts badly to certain medicines. Researchers are trying to understand these reactions through the science of pharmacogenetics

These enzymes also alter a lot of other chemicals in the body. for instance, detoxifying/activating hormones, neurotransmitters etc ('endogenous substrates').

drug metabolizing enzymes


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