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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Thursday, October 9, 2008

The role of the dorsal tongue, scraping, and bad breath

This article published in The Journal of Contemporary Dental Practice, presents three studies carried out from 1992 through 1997 on the source of volatile sulphur compound (VSC) production and tongue coating. It highly supports the practice of tongue scraping for the longer lasting reductions in VSC levels. It identified several malodourous bacteria, such as Bacteroides, Fusobacteria spp., Peptococcus., and Peptostreptococcus, amongst the prominent cultivable microbiata.

Recent studies implicate the dorsum of the tongue as the primary source of VSC production both in periodontally healthy and diseased populations. These studies demonstrate (1) that removal of the tongue coating reduces VSC production and (2) when comparisons are performed in samples of mouth air following tongue scraping, tooth brushing, and rinsing with water in subjects with malodour, the longer lasting reductions in VSC levels are followed after tongue scraping.(1)
In the previous page, there is an article entitled, Fundamentals of Breath Malodour, The Role of Substrates, it explains the composition of saliva and the effects of an increased pH. TMA has an alkaline pH of 9.8, whereas the average pH range of both urine and saliva is approximately at 6.4.

Various authors have tried to reproduce the halitosis process in the laboratory by incubating saliva under different conditions. Saliva consists of a complex mixture of secretions from the salivary glands together with multiple species of bacteria, desquamated epithelial cells, leukocytes, and food remnants. Under healthy conditions, saliva does not have an odour. When its pH is increased, however, it turns into an increasingly putrefied odour.(2)
It would seem that since lemon juice has a pH range of 1.8 to 2.3, it would stand to reason that putting a few drops of sugar-free lemon juice various times a day on the dorsum of the tongue after tongue scraping in an effort to decrease the pH, thus creating an unfavorable environment for bacterial overgrowth. On the other hand, it's also imptorant to not let the lemon juice stay on your teeth for an extended period of time, as it may be harmful to the tooth enamel.


The Journal of Contemporary Dental Practice, Volume 2, Number 4, November 15, 2001, Fall Issue


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