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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Thursday, October 9, 2008

The role of the dorsal tongue, scraping, and bad breath

This article published in The Journal of Contemporary Dental Practice, presents three studies carried out from 1992 through 1997 on the source of volatile sulphur compound (VSC) production and tongue coating. It highly supports the practice of tongue scraping for the longer lasting reductions in VSC levels. It identified several malodourous bacteria, such as Bacteroides, Fusobacteria spp., Peptococcus., and Peptostreptococcus, amongst the prominent cultivable microbiata.

Recent studies implicate the dorsum of the tongue as the primary source of VSC production both in periodontally healthy and diseased populations. These studies demonstrate (1) that removal of the tongue coating reduces VSC production and (2) when comparisons are performed in samples of mouth air following tongue scraping, tooth brushing, and rinsing with water in subjects with malodour, the longer lasting reductions in VSC levels are followed after tongue scraping.(1)
In the previous page, there is an article entitled, Fundamentals of Breath Malodour, The Role of Substrates, it explains the composition of saliva and the effects of an increased pH. TMA has an alkaline pH of 9.8, whereas the average pH range of both urine and saliva is approximately at 6.4.

Various authors have tried to reproduce the halitosis process in the laboratory by incubating saliva under different conditions. Saliva consists of a complex mixture of secretions from the salivary glands together with multiple species of bacteria, desquamated epithelial cells, leukocytes, and food remnants. Under healthy conditions, saliva does not have an odour. When its pH is increased, however, it turns into an increasingly putrefied odour.(2)
It would seem that since lemon juice has a pH range of 1.8 to 2.3, it would stand to reason that putting a few drops of sugar-free lemon juice various times a day on the dorsum of the tongue after tongue scraping in an effort to decrease the pH, thus creating an unfavorable environment for bacterial overgrowth. On the other hand, it's also imptorant to not let the lemon juice stay on your teeth for an extended period of time, as it may be harmful to the tooth enamel.


The Journal of Contemporary Dental Practice, Volume 2, Number 4, November 15, 2001, Fall Issue


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