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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU UK end total:262
TMAU UK ends 23/01/20
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USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
click to read more
more details : karen.james@meboresearch.org

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Thursday, October 9, 2008

The role of the dorsal tongue, scraping, and bad breath






This article published in The Journal of Contemporary Dental Practice, presents three studies carried out from 1992 through 1997 on the source of volatile sulphur compound (VSC) production and tongue coating. It highly supports the practice of tongue scraping for the longer lasting reductions in VSC levels. It identified several malodourous bacteria, such as Bacteroides, Fusobacteria spp., Peptococcus., and Peptostreptococcus, amongst the prominent cultivable microbiata.

Recent studies implicate the dorsum of the tongue as the primary source of VSC production both in periodontally healthy and diseased populations. These studies demonstrate (1) that removal of the tongue coating reduces VSC production and (2) when comparisons are performed in samples of mouth air following tongue scraping, tooth brushing, and rinsing with water in subjects with malodour, the longer lasting reductions in VSC levels are followed after tongue scraping.(1)
In the previous page, there is an article entitled, Fundamentals of Breath Malodour, The Role of Substrates, it explains the composition of saliva and the effects of an increased pH. TMA has an alkaline pH of 9.8, whereas the average pH range of both urine and saliva is approximately at 6.4.

Various authors have tried to reproduce the halitosis process in the laboratory by incubating saliva under different conditions. Saliva consists of a complex mixture of secretions from the salivary glands together with multiple species of bacteria, desquamated epithelial cells, leukocytes, and food remnants. Under healthy conditions, saliva does not have an odour. When its pH is increased, however, it turns into an increasingly putrefied odour.(2)
It would seem that since lemon juice has a pH range of 1.8 to 2.3, it would stand to reason that putting a few drops of sugar-free lemon juice various times a day on the dorsum of the tongue after tongue scraping in an effort to decrease the pH, thus creating an unfavorable environment for bacterial overgrowth. On the other hand, it's also imptorant to not let the lemon juice stay on your teeth for an extended period of time, as it may be harmful to the tooth enamel.

(1) http://www.thejcdp.com/issue008/sanz/12sanz.htm
(2) http://www.thejcdp.com/issue008/sanz/11sanz.htm

The Journal of Contemporary Dental Practice, Volume 2, Number 4, November 15, 2001, Fall Issue

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