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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Wednesday, December 3, 2008

Can TMA producing bacteria cause a choline deficiency in the host ?

Obviously someone on a low choline diet has to think about the concern of giving themselves a choline deficiency; but ironically, in theory, it must seem possible that someone with a lot of trimethylamine-producing bacteria in their gut may also end up with a choline deficiency due to the bacteria 'eating' the choline and giving the host lots of trimethylamine instead. Choline has been associated with fatty liver (it's a very common ingredient in liver detox supplements, since it's 'lipotropic' quality is thought to make it a good liver 'decongestor'). It wasn't classified as an essential nutrient by the National Academy of Sciences until 1998. The gut ecology can play a big role in what we end up 'absorbing' (both good and bad). for example, many of the B vitamins are produced by good bacteria in our gut. Conversely, as in this case, factors in the gut can mean you end up deficient in certain nutrients, either through the altered gut flora 'eating' the nutrient themselves, or the 'friendly' bacteria which produce good nutrients being depleted (and probably other reasons).

Recent metagenomic studies have also shown a strong interaction between gut flora and detoxification of xenobiotics
In this 2006 study, which involved Dr Stephen Mitchell who is an FMO3 expert in London, they found that mice with too much trimethylamine-producing bacteria in their gut did in effect have a blood 'choline deficiency' despite choline being in their diet, when they tested the plasma phospatidylcholine levels.

Testing B vitamin status (or associated nutrients) in metabolic body odor and halitosis cases would seem a sensible 'checklist' option for individuals and in metabolic body odor and halitosis studies (for instance, by a BO & halitosis research center).

Pubmed paper 2006: Abstract : Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.
Full paper on site

related links and info:
Linus Pauling Institute entry for Choline
Healthworld Online article on Choline by Elson Haas
test used in the study: plasma phosphatidylcholine levels

Choline properties:
Is a methyl donor in methylation
Is a fat 'emulsifier/decongestant'
Important part of the neurotransmitter acetylcholine

Blog suggestion: group get an idea of choline plasma blood levels, whether on the TMAU diet or think they may have TMAU.

Gut Microbiota Mimic Choline-Deficient Diets.

Choline-deficient diets have been consistently associated with hepatic steatosis, which is reversible by choline i.v. infusion (12). We have also shown that quantitative variation in dietary choline induces an inverse quantitative variation in liver fat content (see Fig. 9). We show here that lower plasma PC levels in strain 129S6 on HFD compared with BALB/c mice can be explained by reduced bioavailability of choline (see Fig. 8) because of conversion of choline into methylamines by gut microbiota, with subsequent urinary excretion. This mechanism thus mimics a choline-deficient diet. This microbiota-related reduced choline bioavailability may result in the inability to synthesize PC necessary for the assembly and secretion of very-low-density lipoprotein (VLDL) (37) and subsequent accumulation of TG in liver. Methylamines also induce hepatotoxicity and hepatocarcinogenicity in rats (38). Indeed, microsomal FMO-detoxification enzymatic systems have been evolutionarily coselected toward the assimilation of biologically active natural compounds involved in biological defense signaling (39). This enzymatic system detoxifies soft nucleophilic functional groups of natural origin, such as alkaloids, with basic side chains, and organic sulfur xenobiotics. Microbiota-derived methylamines, predominantly excreted in urine, share the same metabolic detoxification process and may also share the same toxicity as other soft nucleophiles. Recent metagenomic studies have also shown a strong interaction between gut flora and detoxification of xenobiotics


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