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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Thursday, January 15, 2009

Women's Conference Call topic of discussion: treating vaginal odor

Our Women’s Conference Call yesterday was primarily about medical treatments prescribed by our gynecologists and remedies that have worked for some of us with vaginal odor. Women who suffer from a body odor condition in which volatile organic compounds (VOCs) are found in their blood and released through their breath, their skin through oils and perspiration, urine, and vaginal fluids seem to develop a secondary condition involving a very alkaline vaginal environment that is conducive to a microbiota imbalance.

As we have discussed in the past, a metabolic BO sufferer’s usual body odor is heightened before and during menstruation as a result of the hormonal changes that take place at this time of the month. After consulting with their gynecologist, some women have opted to use Depo Provera (medroxyprogesterone) injections to almost completely eliminate or completely eliminate ovulation and menstruation. With this hormonal treatment, women are able to forego the more odorous time of the month because in addition to preventing ovulation this hormonal treatment also changes the cervical mucus and uterine lining.

For this same purpose, some women have also taken Ortho Cyclen (ethinyl estradiol and norgestimante) under their gynecologists’ care. This combination of female hormones prevents ovulation resulting in changes in the cervical mucus and uterine lining.
Some of the VOCs, such as trimethylaminuria (TMA) are very alkaline (have a high pH). When the pH is not balanced at or around 4.5, an overgrowth of certain microbiota in the vagina may occurs, thus yeast or bacterial (gardnerella) infections may develop. See post in this blog entitled, ‘Non-infectious and infectious causes of vaginal odor'.

Due to the close proximity of the urethra to the vagina, bladder infections may also develop. Both need to be treated together or they will continue to contaminate each other resulting in a long term condition. Some gynecologists have prescribed Aci-Jel (Acid Gellant) to some of the ladies, which is a bland non-irritating, water-dispersible, buffered acid jelly for intra-vaginal use.

Due to the close proximity of the urethra to the vagina, bladder infections may also develop. Both need to be treated together or they will continue to contaminate each other resulting in a long term condition. Some gynecologists have prescribed Aci-Jel (Acid Gellant) to some of the ladies, which is a bland non-irritating, water-dispersible, buffered acid jelly for intra-vaginal use. Aci-Jel has a pH of 1.6 and lowers the vaginal pH to 4.5 when used every 3 days. By stabilizing the vaginal pH, a healthy microbiota balance can be maintained.

One of the women on the call was concerned about the fact that Aci-Jel contains egg albumen (egg whites), and wondered if it would be high in choline, and we had a discussion about egg whites not being high in choline, but instead the egg yolk is high in choline. In addition, the amount would be very small, and we were not convinced that it would permeate into the bloodstream, so we felt that it should not contribute to the odor. Nonetheless, women who have sensitivity to egg products should consult with their physician before using this prescription medication.

In addition to the above-mentioned prescription medications, we discussed the benefits of a probiotic specifically designed for women, called Fem-Dophilus® from Jarrow. As far as we know, it could only be purchased only online.

After all this discussion, we reiterated to each other the importance of a proper diet to control the VOCs in our blood that in addition to producing odor, may also be altering our vaginal pH resulting in odorous infections as well. We also strongly emphasized the importance of consulting with one's gynecologist before undergoing any hormonal treatment or using any prescription medication.

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