Admin Control Panel

New Post | Settings | Change Layout | Edit HTML | Edit posts | Sign Out
March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country
MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed

Subscribe to Blog

Enter your email address:

Delivered by FeedBurner

You will be sent a verification email

Subscribe in a reader

Blog Archive

UK residents survey : Prof Shephard/MEBO (until 31/1/21) click to visit survey
click to Read more/less

Prof Elizabeth Shephard is conducting a TMAU fact-finding survey for UK RESIDENTS. She plans to use it to raise awareness with decision-makers, such as perhaps MPs. It closes 31 Jan 21.

who is the survey intended for ?
UK residents who identify with TMAU

Living with TMAU study

We invite you to participate in a research project entitled ‘Living with TMAU’.

click to visit survey

survey full url :
https://meboresearch.co.uk/index.php/living-with-tmau-lwtmau-study/

Participation in the project will involve completion of a short questionnaire, which aims to capture the experiences of those living with the condition. There are two questionnaires.

For individuals with TMAU over the age of 18

For a parent or guardian of a child with TMAU.

The results from the questionnaires will be compiled to produce a report that will be available for you to use, for example, to lobby your MP. The findings will be used to reach out to policy makers in the UK to have TMAU recognised as an invisible disability and to make people aware of what it is like to live with the disorder. The report will be made available on the MEBO, UK website.

To complete either questionnaire you must be over 18 and resident in the UK. The questionnaire responses are anonymous and no personal identifiers will be collected.

The questionnaire closes 11:59 pm (GMT) Sunday 31st January 2021.

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Sunday, May 3, 2009

Christodoulou TMAU research proposal : Methylophilus methylotrophus as a TMAU probiotic

In the trimethylaminuria research proposal by Dr Christodoulou et al, he proposes trying 2 methods of treatments (albeit, on mice). The first is using PCT124/Ataluren to see if it can negate a nonsense mutation in primary trimethylaminuria. This would only be of benefit (if it works) to the subset of sufferers who have primary TMAU due to nonsense mutations.

The other method would potentially be of benefit to all sufferers. It has long been mentioned that if a bacteria/probiotic could detoxify trimethylamine in the gut, then it could do the (gut) detoxifying for the person. The long-speculated suggestion was for a bacteria engineered to be rich in FMO3. Dr Christodoulou is proposing to use a known harmless bacteria (Methylophilus methylotrophus) that, instead, detoxifies trimethylamine by an alternative pathway. Rather than FMO3 (which changes it to trimethylamine-n-oxide, the trimethylamine will be altered to dimethylamine and formaldehyde by an enzyme in the bacteria (trimethylamine dehydrogenase).

Not knowing anything of the metabolic differences, a first impression is that an FMO3 enriched bacteria would seem preferable, since the by-products of the other pathway don't seem too nice-sounding (dimethylamine and formaldehyde). Also, FMO3 is a commonly used enzyme, dealing with probably 1000s of substrates that are amines, sulfides, or phosphorous containing. Most of these substrates can go a slower more complicated alternative route if necessary, but in humans, TMA cannot (hence possibly the reason researchers feel TMA is the only smell issue with FMO3). Since most seem to say they can smell of all sorts of smells, you have to wonder if the whole xenobiotic-metabolizing-enzyme system is becoming 'backed up' with other typical FMO3 substrates, with TMA being a baseline problem? Or perhaps TMA is an inhibitor of these enzymes? For these types of reasons, it would seem preferable to have an FMO3-rich bacteria, but maybe this is not currently possible, or for logistical reasons. So Dr Christodoulou has gone for a bacteria known to have trimethylamine-dehydrogenase enzyme, an enzyme which humans don't possess.

However this may be unimportant and we are grateful for any research. It would be interesting to know if this bacteria is available. It is possibly used in the agricultural industry as a source of food for pigs. But nobody likely knows the potential averse reactions in humans. At this stage, we can only wait to see how the mice get on, although these 2 treatment stages aren't planned until year 3.
Other strategies for metabolising TMA in the small intestine:
Anaerobic gut bacteria can contribute to the trimethylamine load in patients with TMAU by enhancing the metabolism of choline in food to trimethylamine in the gut1. As stated above, one form of therapy of TMAU, albeit in more extreme cases, is to treat patients with antibiotics aiming to reduce the intestinal load of these bacteria. However, the antibiotics that need to be used have potentially serious side effects, and so can only be used for short periods of time.
An alternative strategy for reducing the gut trimethylamine load would be to colonise the gut with harmless bacteria that are capable of metabolising trimethylamine. One such micro-organism is Methylophilus methylotrophus. This is an aerobic monoflagellate bacterium that uses methanol as the sole source of carbon and energy16. It was initially thought to be of potential commercial value in the single-cell protein production industry, but it proved to be a nonfinancial venture. When cultured in trimethylamine, the enzyme trimethylamine dehydrogenase is induced, which converts trimethylamine to dimethylamine and formaldehyde17. Extensive studies have shown that this micro-organism is non-pathogenic and non-toxic in animals18, 19. Therefore colonisation of the gut with Methylophilus methylotrophus in individuals with TMAU could be of potential therapeutic utility.

2 comments:

Anonymous said...

Is there a cure then?

Jan 26, 2013, 7:27:00 PM
blogcontributor2 said...

Hi

If you mean this,the funding was never raised so it was never tried.

In theory there are probably similar things that could be tried to reduce or metabolise TMA production, although currently it is not known if anyone is trying to do this.

Jan 26, 2013, 11:31:00 PM
Post a Comment