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MEBO - UBIOME study 2018

NCT03582826
ClinicalTrials.gov
MEBO Gut Microbiome Study
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Ubiome Gut EXPLORER : 10% OFF
Join/Watch the weekly
TMAU UP Podcasts

Videos : TMAU stories

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact map@meboresearch.org
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
BannerFans.com
RESEARCH DETAILS

DONATIONS THRU 31-NOV-2016:
£ 943.03/GBP
$ 568.00/USD

TOTAL at today's ROE
£0.80/GBP = $1.00/USD

£1,398.07 = $1,745.14

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Blog Archive

Friday, May 1, 2009

Summary Blog posts on vitamins/minerals

...vitamins and minerals to optimize genetic enzyme weaknesses
1. Post title: Want to build muscle and need extra protein with your choline diet? It is safer to just go with the egg whites, since 1/4 cup/60g weight of liquid egg whites contain 1.410mg of choline and 0.250mg of betaine. I think it would be safe to say that you can have this a number of times a day as you keep track of your choline intake to your personal non-odor producing level.

Recommends a multivitamin that contains 100% of the DRI for vitamins and minerals, particularly folate [FOLIC ACID] and riboflavin [VITAMIN B2].

2. Post title: Vitamin & mineral deficiencies : An unknown quantity in bloodborne odors The status of the B Vitamins is probably a good starting point, since they are often co-factors in the drug metabolizing enzymes (the xenobiotic enzymes, of which the FMO family of enzymes are a part of). B Vitamins are also often produced by good gut bacteria [ so probiotics helps]. Biotin in particular.

3. Post title: Probiotics: Metabolic interactions in the gut One of the most important ways in which a probiotic organism may exert a beneficial effect on its host is to modify metabolic processes, particularly those occurring in the gut. Such a beneficial effect could be achieved in theory by a variety of mechanisms:

  • By suppressing reactions which result in the generation of toxic or carcinogenic metabolites.
  • By stimulating enzymic reactions involved in detoxification of potentially toxic substances, either ingested or formed endogenously.
  • By stimulating mammalian enzymes involved in the digestion of complex nutrients, or when such enzymes are absent (due to genetics or disease) providing a bacterial source of these enzymes.
  • By synthesizing vitamins and other essential nutrients not provided in sufficient quantities in the diet...
4. Post title: Comments posted in this blog "It might be dangerous to use charcoal in the long term because 'In addition to adsorption of toxins, activated charcoal also adsorbs food nutrients, vitamins, and minerals.' "

5. Post title: Berkeley press release on the theory of using vitamins and minerals to optimize genetic enzyme weaknesses This is the same as the recent article in a recent post about the potential of vitamins and minerals being used to optimize in-born genetic weaknesses in certain enzymes, but also includes a short video of one of the researchers. It is a Berkeley press release. Many enzymes need a 'co-factor' to function, such as a vitamin or mineral.

6. Post title: Dietary Reference Intakes Tables: Vitamins The table in this article shows the food source, function, and adverse effects of excessive consumption of vitamins. It recommends dosage for life stage groups, and advises of special considerations.

7. Post title: DRI Reprot-Thiamin, Riboflavin, Niacin, Vit B6, Folate, Vit B12, Pantothenic Acid, Biotin, & Choline This DRI [Dietary Reference Intake] report includes the eight water-soluble B complex vitamins — thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline, involved with energy metabolism and single-carbon unit transfer processes. View or download the entire 591 page document or just selected sections below, or find information for obtaining the book version...

8. Post title: Niacin, Vitamin B3, Nicotinic Acid "Niacin (also known as vitamin B3) is found in dairy products, poultry, fish, lean meats, nuts, and eggs. Legumes and enriched breads and cereals also supply some niacin." Many of these are foods high in choline that TMAU sufferers need to stay away from to prevent body odor. Therefore, it's important to review the recommended dose noted in this encyclopedic article to meet the known nutrient needs.

9. Post title: What should be done with the personal donations to MeBO ? One [of mebo’s] idea is to do small anecdotal studies to try to identify a pattern into systemic body odors. An example would be a leaky gut study, where members of the forum are offered the leaky gut test funded by MeBO. This study would not tell us anything conclusive, but if those that participate have leaky gut, it may tell us it could be a factor. Another example is B vitamin status. Many B vitamins are produced by a good gut flora. B vitamins are involved in many enzyme functions (often being a cofactor). If there was a vitamin deficiency involved, it would likely be a B vitamin. These amateur studies are far from ideal, but may tell us something, and are probably more enlightening than where we currently are. These small studies may also act as a focus and a template as to what the group can achieve in the future as well.

Possible areas of speculative testing with personal donation money:

genetics : DNA tests. FMO3 testing. Detoxigenomic test
vitamin status : probably B vitamins mostly
mineral status : Magnesium ?
dysbiosis tests : candida, parasites, etc.
leaky gut testing
Trimethylaminuria testing
Malodorous Volatile Organic Compound testing

10. Post title: Interview : Mark Howard of Biolab Medical Unit, London Biolab is a medical laboratory specialising in nutritional and environmental Medicine. We measure mineral and vitamin levels, toxic metals, other biochemical levels that are related to the availability of vitamins, minerals and other nutrients, and we also have an extensive range of profiles for assessing the effects of Twenty-First century lifestyles on our bodies (Tests).

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