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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Wednesday, September 23, 2009

goals : trimethylamine sensors for home body odor and halitosis checks

One aim of MeBO Research and probably amongst the body odor and halitosis community in general is for the best and easiest ways of diagnosis of whatever their problem is. In the case of TMAU, this currently means using the very few labs that test for TMAU.

There are 2 aspects to testing: 1 is the 'gold standard' tests, that will presumably always be done in labs. The other is 'monitoring' testing, which could probably be done in the home. This would be like the 'digital blood pressure checkers' people can nowadays buy very cheaply.

For monitoring TMAU, the product would likely be based on monitoring trimethylamine levels in the urine (perhaps in the breath ?). This would seem to be likely done in either 2 ways :
1 : test strip paper (such as ph paper or diabetes dipstick paper)
2 : electronic sensors such as used in breathalyzers

Amazingly, both such types of TMA monitoring already exist, primarily designed for the fish industry. The TMA test paper idea seemed to be patented a few years ago in Canada but no product was brought to market due to lack of interest.

Probably one major problem is that these companies do not realise there would likely be a bigger than expected 'medical' market for such devices, thinking TMAu to be very rare.

MeBO Research hopes to encourage such devices, although with such a problem the the old adage seems very appropriate : it doesn't matter where the leads/answers come from.

The following 2 papers are about electronic sensors for TMA. It's not known what has become of these ideas, but it would be very useful if such a sensitive digital checker could be bought for under $50.

France 2009 : Trimethylamine biosensor based on pentacene enzymatic organic field effect transistor

Japan 2004 : Trimethylamine biosensor with flavin-containing monooxygenase type 3 (FMO3) for fish-freshness analysis


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