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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
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BO Sufferers Podcasts

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Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
rareconnect.org TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Wednesday, September 23, 2009

goals : trimethylamine sensors for home body odor and halitosis checks

One aim of MeBO Research and probably amongst the body odor and halitosis community in general is for the best and easiest ways of diagnosis of whatever their problem is. In the case of TMAU, this currently means using the very few labs that test for TMAU.

There are 2 aspects to testing: 1 is the 'gold standard' tests, that will presumably always be done in labs. The other is 'monitoring' testing, which could probably be done in the home. This would be like the 'digital blood pressure checkers' people can nowadays buy very cheaply.

For monitoring TMAU, the product would likely be based on monitoring trimethylamine levels in the urine (perhaps in the breath ?). This would seem to be likely done in either 2 ways :
1 : test strip paper (such as ph paper or diabetes dipstick paper)
2 : electronic sensors such as used in breathalyzers

Amazingly, both such types of TMA monitoring already exist, primarily designed for the fish industry. The TMA test paper idea seemed to be patented a few years ago in Canada but no product was brought to market due to lack of interest.

Probably one major problem is that these companies do not realise there would likely be a bigger than expected 'medical' market for such devices, thinking TMAu to be very rare.

MeBO Research hopes to encourage such devices, although with such a problem the the old adage seems very appropriate : it doesn't matter where the leads/answers come from.

The following 2 papers are about electronic sensors for TMA. It's not known what has become of these ideas, but it would be very useful if such a sensitive digital checker could be bought for under $50.

France 2009 : Trimethylamine biosensor based on pentacene enzymatic organic field effect transistor

Japan 2004 : Trimethylamine biosensor with flavin-containing monooxygenase type 3 (FMO3) for fish-freshness analysis

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