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MEBO - UBIOME study 2018

NCT03582826
ClinicalTrials.gov
MEBO Gut Microbiome Study
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

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Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
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Blog Archive

Thursday, February 25, 2010

More about the ABCC11 gene that seems to cause natural hypohydrosis

Recently we posted about the ABCC11 gene, which seems to co-relate with naturally not being prone to underarm body odor (axillary odor). A sign of having the ABCC11 gene is that your earwax is the dry-type. This seems to be most common in far-east Asia. The following papers go into more detail about the gene. The hypothesis seems to be that it causes a natural hypohydrosis, which makes it more difficult for the axillary bacteria to thrive in the less moist environment. Although it is a 'loss of function' copy of the gene (a mutation), it is no surprise that in the communities where it first came about, now it has become the dominant type for that gene (e.g. mates have preferred those with the mutation. Now at levels of 95% of the communities.)

A functional ABCC11 allele is essential in the biochemical formation of human axillary odor

A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene

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