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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Saturday, March 27, 2010

Comparing UK trimethylaminuria results with USA results

It has been noted on body odor forums; that in the USA and elsewhere, the person usually understand their result as a percentage, but this % does not seem to be commonly used by British testers giving their results.

The percentage is actually the total amount of TMA that the person managed to metabolize to TMA-oxide, giving an idea of the person's FMO3 metabolic capacity (at least, for that test sample). Trimethylamine is probably the 'best' marker for testing FMO3 function, since unlike most other substrates, it cannot go any alternative route for oxidation. That said, you need to make sure enough TMA is in your system to give it a thorough test of TMA oxidation capacity.

For anyone wishing to calculate their 'FMO3 capacity %', it is based on the TMA/TMAO ratio given in the results.

The calculation is :

TMA-oxide/(TMA + TMA-oxide) x 100

This is the % of TMA present you managed to metabolize into TMA-oxide.

With regards what is the % function of normal people, it does not look as if there is a standard 'cut-off' point which all labs agree. A French paper gave the cut-off point for normals as 95%, whereas others seem to go for around 90% or even a bit lower.
(PDF) Dr Eugene Michel 2002 paper : FMO3 capacity greater than 95%

It would seem unlikely that those around 80% would be 'classic' TMAU cases, since the textbooks say a TMAU is someone with 2 mutant copies, which would mean almost no function or a very low % reading. Unfortunately in the case of TMAU, the smell is in the nose of the beholder, and if someone is told they smell and do not have 2 mutant copies, you have to assume that it's not just 'classic' cases that fail the 'smell test'. It would seem more likely that 'mild cases' would be transient. Also, it seems FMO3 may vary at times, such as during menstruation.
2007 TMAU paper : FMO3 and menstruation

With a general glance at genetics, it seems that geneticists class the function of genes into 3 basic groups :
mutant (very poor function. null-alleles etc)
variants/polymorphisms (milder loss of function. Can vary depending on physiological factors)
wild type (milder still ?)

It seems possible that many genetic 'smelly' cases may not be '2 mutant copy' cases, and more a combo of other sub par functioning combinations :
for instance:
1 mutant and a normal copy (? meaning in some cases it may be autosomal dominant)
2 variants

However only the collection of genetic results will be able to clarify this. All of this does not seem to conclusively explain a complaint such as fecal body odor syndrome that most seem to complain of, which seems to imply other factors may be involved with that (either as well, or instead of). MeBO hopes to keep looking for answers to these questions.


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