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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, March 26, 2010

New FMO3 paper : A physiological role for flavin-containing monooxygenase (FMO3) in humans?

Flavin mono oxygenase 3 enzyme seems to be very much the ignored xenobiotic enzyme in medical research, despite dealing with probably thousands of substrates in humans, usually oxidizing soft-nucleophilic heteroatom compounds containing sulfur, nitrogen, or phosphorous to non-toxic excretable oxides. There seem to be few researchers interested, and fewer research papers. Someday the pharmaceutical industry will realize it may be a factor in drug metabolism, as can likely be taken for granted by the amount of TMAU people who anticipate bad reactions to drugs. Currently the only 'downside' of having poor FMO3 function is regarded as trimethylaminuira, so it is likely that without our own actions, it will not be until the pharmaceutical industry realizes the 'drug metabolism' factor that frequent serious research will be done into this enzyme.

One of the 'pioneers' in FMO3 research has been Dr Stephen Mitchell of London, who did most of his FMO3 papers in the late 80's and 90's. He also seemed to have a role in organizing the 1st TMAU workshop in 1999.

He has not published an FMO3 paper for most of the last decade, but recently published a new FMO3 paper along with RL Smith, who also has a history in FMO3 research (again, not recently).

The paper is entitled :
A physiological role for flavin-containing monooxygenase (FMO3) in humans?

Unfortunately for us there is not even an abstract available to the public, so we cannot get a summary of what the paper is about. If anyone has access, it would be interesting to know more.


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