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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
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BO Sufferers Podcasts

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Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Friday, August 13, 2010

1975 Science paper : 7% could not smell trimethylamine

With a systemic body odor problem, including TMAU, it is quite common for the person and their 'loved ones' (e.g. parents, partner, children) to be unable to smell the odor. Speculation as to why this would be varies in the community. Some feel that those close to the person become acclimatized and desensitized to the smell. Others feel that some people are totally anosmic to some smells (specific anosmia). Another theory is a genetic reason, with the 'loved ones' being carriers of the same problem being a factor for some reason.

One can only speculate as to what exactly is happening. There is one published paper of a study in which people's ability to smell a certain group of smells including trimethylamine were tested. Written in 1975, this paper is a study of a group of a couple of hundred people, which demonstrated that 7% of the group had difficulty detecting the smell of tertiary amines, particularly trimethylamine.

Apparently trimethylamine is usually detectable at a very lows level in humans, the lowest of 53 odors tested in one study, including mercaptans and hydrogen sulfide.


In another paper in 1990, 11.5% of children could not have their detection of TMA measured, which may indicate an anosmia, but the paper says this may be due to them losing interest in the study.




other links of interest

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